Synthesis and characterization of biocompatible hydrogel based on hydroxyethyl cellulose- g -poly(hydroxyethyl methacryl
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Synthesis and characterization of biocompatible hydrogel based on hydroxyethyl cellulose‑g‑poly(hydroxyethyl methacrylate) Naglaa Salem El‑Sayed1,4 · Hanem Awad2 · Ghada M. El‑Sayed3 · Zenat A. Nagieb1 · Samir Kamel1 Received: 30 July 2019 / Revised: 12 September 2019 / Accepted: 14 September 2019 © Springer-Verlag GmbH Germany, part of Springer Nature 2019
Abstract A novel polymeric hydrogel composed of hydroxyethyl cellulose-g-poly(2-hydroxyethyl methacrylate) was prepared via graft polymerization of hydroxyethyl methacrylate on the surface of hydroxyethyl cellulose. N,Nʹ-Methylenebisacrylamide was used as a cross-linker. In this work, we changed the ratio of hydroxyethyl cellulose to the monomer, while the potassium persulfate and the cross-liker were used in amounts proportional to the wt% of both the matrix and monomer. The copolymers formation was confirmed by infrared spectroscopy and X-ray diffraction pattern, while the changes in the surface morphology of the hydrogel were examined by scanning electron microscopy. The increase in the monomer ratio gradually improved the thermal stability of the resultant hydrogels. Finally, the cytotoxicity of the new polymeric hydrogels was evaluated using HCT-116, HepG2, MCF-7 human cancer cell lines and RPE-1 normal cell line. The cytotoxicity studies showed that the hydrogels were selectively toxic against the tested human cancer cell lines in a dose-dependent manner, whereas their cytotoxic activity was significantly reduced when they incubated with human RPE-1 normal cell lines, suggesting their possible utility in the formulation of anticancer drugs. Keywords Hydroxyethyl cellulose · 2-Hydroxyethyl methacrylate · Graft polymerization · Hydrogel · Biocompatibility · Cytotoxicity
Introduction The biocompatibility, biodegradability and outstanding physicochemical properties of water-soluble cellulose ethers such as hydroxypropylmethyl cellulose (HPMC), methyl cellulose (MC), hydroxyethyl cellulose (HEC) and * Samir Kamel [email protected] Extended author information available on the last page of the article
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carboxymethyl cellulose (CMC) made them suitable candidates for their use in food industry as thinking and emulsifying agents as well as their wide applications in the pharmaceutical industries as matrix components in formulations of many therapeutic agents owing to their ability to sustain the drug release from the tablets [1]. So far, the problems of poor mechanical properties, limited solubility in physiological solutions, the uncontrolled water uptake and drug release profiles of microbial contamination and change in viscosity on storing for prolonged time represent the main hinders that need intensive research for more optimization [2]. The literature is rich in scientific reports focusing on modulating their physicochemical and biological properties using different approaches. Among these approaches is the graft polymerization of different synthetic polymers on the surface of WSCEs [3–6]. Graft copolymerization
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