Systems Biology of Alzheimer's Disease
Alzheimer’s disease (AD) and many other neurodegenerative disorders are multifactorial in nature, involving a combination of genomic, epigenomic, network dynamic, and environmental factors. A proper investigation requires new integrative Systems Biology a
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Juan I. Castrillo Stephen G. Oliver Editors
Systems Biology of Alzheimer’s Disease
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Systems Biology of Alzheimer’s Disease Edited by
Juan I. Castrillo Department of Biochemistry & Cambridge Systems Biology Centre, University of Cambridge, Cambridge, UK; Genetadi Biotech S.L. Parque Tecnológico de Bizkaia, Derio, Bizkaia, Spain
Stephen G. Oliver Department of Biochemistry & Cambridge Systems Biology Centre, University of Cambridge, Cambridge, UK
Editors Juan I. Castrillo Department of Biochemistry & Cambridge Systems Biology Centre University of Cambridge Cambridge, UK
Stephen G. Oliver Department of Biochemistry & Cambridge Systems Biology Centre University of Cambridge Cambridge, UK
Genetadi Biotech S.L. Parque Tecnológico de Bizkaia Derio, Bizkaia, Spain
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-2626-8 ISBN 978-1-4939-2627-5 (eBook) DOI 10.1007/978-1-4939-2627-5 Library of Congress Control Number: 2015943618 Springer New York Heidelberg Dordrecht London © Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Cover illustration: Photomicrograph of stained sections, neurons and dendrites in the parahippocampal cortex of a patient whose soma contains anti-paired helical filaments (PHF-tauAT8) in the putative pre-tangle state. Image reproduced from (Merino-Serrais et al (2013) Brain 136, 1913). Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License. Printed on acid-free paper Humana Press is a brand of Springer Springer Science+Business Media LLC New York is part of Springer Science+Business Media (www.springer.com)
Preface Alzheimer’s disease (AD), the most common form of dementia, currently affects over 44 mil
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