The Future of Aging Pathways to Human Life Extension
Just as the health costs of aging threaten to bankrupt developed countries, this book makes the scientific case that a biological "bailout" could be on the way, and that human aging can be different in the future than it is today. Here 40 authors argue ho
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Gregory M. Fahy · Michael D. West · L. Stephen Coles · Steven B. Harris Editors
The Future of Aging Pathways to Human Life Extension
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Editors Gregory M. Fahy Intervene Biomedical, LLC Box 478 Norco CA 92860 USA [email protected] L. Stephen Coles Institute of Molecular Biology Department of Chemistry and Biochemistry Young Hall University of California Los Angeles CA 90095-1569 USA [email protected]
Dr. Michael D. West BioTime, Inc. 1301 Harbor Bay Parkway Alameda CA 94502 USA [email protected] Steven B. Harris Critical Care Research, Inc. 10743 Civic Center Drive Rancho Cucamonga CA 91730 USA [email protected]
ISBN 978-90-481-3998-9 e-ISBN 978-90-481-3999-6 DOI 10.1007/978-90-481-3999-6 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2010927444 © Springer Science+Business Media B.V. 2010 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Cover illustration: On the cover: The small nematode worm, C. elegans (wavy lines), can realize some very large gains in lifespan. Compared to the standard N2DRM (wild-type) worm, worms with a strong mutation in a single gene (the age-1 (mg44) allele) can live 10 times longer, and can do so in excellent health. This striking result brings into question the very nature of aging, and raises the possibility of someday extending the lifespans of humans in good health as well. The latter subject is the theme taken up in this book. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
This book is dedicated to the fond memory of Christopher B. Heward, Ph.D., a tireless and dedicated clinical biogerontologist and a superb laboratory scientist who worked at the interface of business and biomedicine as the President of the Kronos Science Laboratories, where he conceived and pursued a variety of research and development projects aimed variously at early detection and prevention of age-related diseases and understanding and slowing the aging process in patients. He was internationally recognized as a seminal thinker in the area of biological aging and was the author and co-author of numerous scientific articles and book chapters. He was a consummately skeptical enthusiast for interventive gerontology. It is an extreme and tragic irony that Chris developed cancer at a relatively young age and died on January 10, 2009 after a vigorous 3-month battle. He set a magnificent example of how to live life courageously to the fullest without illusion. He will be sorely missed by all who knew him.
Preface
Biogerontology is coming of age. It now seems clear that a fundamental understanding of the molecular pathways underlying age-related pathology
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