The protective effect of alpha lipoic acid (ALA) on social interaction memory, but not passive avoidance in sleep-depriv
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ORIGINAL ARTICLE
The protective effect of alpha lipoic acid (ALA) on social interaction memory, but not passive avoidance in sleep-deprived rats Maede Rezaie 1 & Mohammad Nasehi 2 & Salar Vaseghi 2,3 & Mohammad-Hossein Mohammadi-Mahdiabadi-Hasani 4 & Mohammad-Reza Zarrindast 3,5,6 & Mohammad Ali Nasiri Khalili 1 Received: 19 December 2019 / Accepted: 2 June 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Sleep is involved in maintaining energy, regulating heat, and recovering tissues. Furthermore, proper cognitive functions need sufficient sleep. Many studies have revealed the impairment effect of sleep deprivation (SD) on cognitive functions including learning and memory. Alpha lipoic acid (ALA) is a potent free radical scavenger, biological antioxidant, and neuroprotective agent. Furthermore, ALA improves learning and memory performance, decreases oxidative stress, and enhances antioxidant biomarkers. In this study, we aimed to investigate the effect of ALA on social interaction and passive avoidance memories in sleep-deprived rats. Total sleep deprivation (TSD) apparatus was used to induce SD (for 24 h). Three-chamber paradigm test and shuttle box apparatus were used to evaluate social interaction and passive avoidance memory, respectively. Rats’ locomotor apparatus was used to assess locomotion. ALA was administered intraperitoneally at doses of 17 and 35 mg/kg for 3 consecutive days. The results showed SD impaired both types of memories. ALA at the dose of 35 mg/kg restored social interaction memory in sleep-deprived rats; while, at the dose of 17 mg/kg attenuated impairment effect of SD. Moreover, ALA at the dose of 35 mg/kg impaired passive avoidance memory in sham-SD rats and at both doses did not rescue passive avoidance memory in sleep-deprived rats. In conclusion, ALA showed impairment effect on passive avoidance memory, while improved social interaction memory in sleep-deprived rats. Keywords Alpha lipoic acid (ALA) . Sleep deprivation (SD) . Social memory . Passive avoidance . Rats
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00210-020-01916-z) contains supplementary material, which is available to authorized users. * Mohammad Ali Nasiri Khalili [email protected] 1
Department of Bioscience and Biotechnology, Malek Ashtar University of Technology, P.O. Box: 13145-784, Tehran, Iran
2
Cognitive and Neuroscience Research Center (CNRC), Amir-Almomenin Hospital, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
3
Department of Cognitive Neuroscience, Institute for Cognitive Science Studies (ICSS), Tehran, Iran
4
Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
5
Department of Pharmacology School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
6
Department of Neuroendocrinology, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran
Introduction Sleep is a protective c
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