The seropervelance of infectious hepatitis viruses (HBV, HCV and HEV) among blood donors and their correlation to risk f
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ORIGINAL ARTICLE
The seropervelance of infectious hepatitis viruses (HBV, HCV and HEV) among blood donors and their correlation to risk factors in Qena governorate, Upper Egypt Azza Masoud Abdelbaky Ahmed1,2,3 • Hanan Abdelftah Temerk3 • Hamdi Ramdan Galal3 • Shamardan Ezzeldin S. Bazeed4 • Serageldeen Sultan1
Received: 29 January 2020 / Accepted: 24 April 2020 Ó Indian Virological Society 2020
Abstract This study was performed to determine the prevalence of HBV and HCV infection among blood donors and the occurrence of HEV in hepatitis viruses seropositive blood donors. Also, to investigate the correlation between the occurrence of hepatitis viruses and other risk factors (gender, age, occupation, educational level, residency and donors’ types). A total of 11,604 blood samples from apparently healthy blood donors of age range 18–60 years old were collected. The blood donors were categorized as voluntary and replacement donors. Blood samples from donors were tested for the presence of HBsAg, HCV and HEV antibodies by using Enzymelinked immunosorbent assay. The overall results indicated that 671 out of 11,604 blood donors; 370 persons (3.188%) HCV, 295 persons (2.542%) HBV and 6 persons (0.052%) HCV and HBV; were hepatitis viruses seropositive donors. The prevalence of HEV were 193 (28.76%) among these seropositive blood donors. There is a highly significant correlation among HCV, HBV and other risk factors. Also, the HEV showed high significant with age and educational level and significant with donor types and locations. All investigated virus combinations (HEV/HCV, HEV/HBV
& Serageldeen Sultan [email protected] 1
Department of Microbiology, Virology Division, Faculty of Veterinary Medicine, South Valley University, 83523 Qena, Egypt
2
National Blood Bank Services, Qena, Egypt
3
Department of Botany, Faculty of Science, South Valley University, 83523 Qena, Egypt
4
Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, South Valley University, 83523 Qena, Egypt
and HEV/HCV/HBV) were highly significant with the risk factors except for occupation. In conclusion, the HEV is significantly correlated to HCV and HBV seropositive donors and should be screened among blood donors. Keywords HCV HBV HEV Blood donors Risk factors
Introduction Although blood donation saves millions people lives the transfusion transmissible infections (TTIs) through unsafe blood transfusion expose millions people to the risk of pathogens infection [1]. The hepatitis B virus (HBV), and hepatitis C virus (HCV), are prevalent in blood donors worldwide [2]. Hepatitis E virus (HEV) has also been recorded as TTIs [3]. HBV and HCV infections are a serious global public health problem, especially in developing countries [4]. HBV belongs to the genus Orthohepadnavirus in the family Hepadnaviridae. It is hepatotropic partially double stranded circular DNA virus that infects humans and some animals as chimpanzees and birds. Globally, over 350 million people have developed chronic hepatitis infection out o
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