Tissue Engineering in Regenerative Medicine
Over the past decade, significant advances in the fields of stem cell biology, bioengineering, and animal models have converged on the discipline of regenerative medicine. This volume provides a state-of-the-art report on tissue engineering toward the goa
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Series Editor Kursad Turksen, Ph.D. [email protected]
For further volumes: http://www.springer.com/series/7896
Harold S. Bernstein Editor
Tissue Engineering in Regenerative Medicine
Editor Harold S. Bernstein Cardiovascular Research Institute Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Department of Pediatrics University of California San Francisco San Francisco, CA, USA [email protected]
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This book is dedicated to my father, Wallace Carl Bernstein (1923–2010), who taught me to ask questions.
Preface
Over the past decade, significant advances in the fields of stem cell biology, bioengineering, and animal models have converged on the discipline of regenerative medicine. Significant progress has been made leading from preclinical studies through phase 3 clinical trials for some therapies. This volume provides a state-of-the-art report on tissue engineering toward the goals of tissue and organ restoration and regeneration. Examples from different organ systems illustrate progress with growth factors to assist in tissue remodeling; the capacity of stem cells for restoring damaged tissues; novel synthetic biomaterials to facilitate cell therapy; transplantable tissue patches that preserve three-dimensional structure; synthetic organs generated in culture; aspects of the immune response to transplanted cells and materials; and suitable animal models for nonhuman clinical trials. Tissue regeneration, and even stem cell therapy, is not a new concept. As discussed in the cautionary first chapter, efforts toward bone and marrow transplantation have been underway for almost half a century. Steady progress has been made in understanding the criteria for successful cell transplantation, and developing a robust structure for clinical oversight. More recently, pluripotent stem cells, with their capacity for self-renewal and tissue-specific differentiation, have become a prime candidate for tissue engineering and regenerative therapies. More than 100 clinical trials have examined the use of mesenchymal stem/stromal cells. Biochemical and mechanical interactions bet
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