Ulcerogenic and intestinal motility/transit stimulating actions of nevirapine in albino Wistar rats
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ORIGINAL PAPER
Ulcerogenic and intestinal motility/transit stimulating actions of nevirapine in albino Wistar rats Elizabeth Bassey Umoren & Agona Odeh Obembe & Eme Effiom Osim
Received: 27 October 2012 / Accepted: 30 January 2013 / Published online: 28 March 2013 # University of Navarra 2013
Abstract The antiretroviral is a non-nucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1. This study was undertaken to investigate the effect of nevirapine (NVP) administration on gastric acid secretion, pepsin secretion, mucosal secretion, intestinal motility, and transit using apparently healthy albino Wistar rats. Eighty albino Wistar rats (50–125 g body weight) from the start of the experiment were used for the study. Rats in the control group were fed normal rodent chow, while the NVP group was fed by gavage NVP (0.4 mg/kg body weight) two times daily (07:00 and 18:00 hours) in addition to normal rodent chow for 12 weeks. All animals were allowed free access to clean drinking water. Mean basal gastric output and peak acid output following histamine administration in the NVPtreated group were significantly higher (p
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