Without insight accompanied with deteriorated brain functional alterations in healthy individuals with auditory verbal h
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ORIGINAL RESEARCH
Without insight accompanied with deteriorated brain functional alterations in healthy individuals with auditory verbal hallucinations: a pilot study Chuanjun Zhuo 1,2,3,4,5,6 & Feng Ji 1 & Xiaodong Lin 2 & Hongjun Tian 3 & Lina Wang 3 & Sha Liu 4,5 & Hong Sang 6 & Wenqiang Wang 7 & Chunmian Chen 2
# The Author(s) 2019
Abstract Few studies have reported on brain functional differences between healthy individuals with auditory verbal hallucinations (HiAVH) with and without insight, so we designed a study to address this knowledge gap. We enrolled 12 Hi-AVH with insight, 15 Hi-AVH without insight, and 15 AVH-free controls (Healthy controls). Global functional connectivity density (gFCD) mapping was used to estimate brain networks. We found that the most common alterations in both Hi-AVH groups were increased gFCD in superior parietal lobule and superior temporal gyrus. We also found that distinct brain functional patterns of Hi-AVH without insight comprised lower gFCD in the frontal lobe oculomotor area, dorsolateral prefrontal cortex, supramarginal gyrus, primary auditory cortex, sensorimotor cortex, ventral anterior, and posterior cingulate Our pilot findings support the hypothesis that abnormal reciprocal action in the circuits for processing perception, memory, language, and attentional control may be pathological features of auditory verbal hallucinations.
* Chuanjun Zhuo [email protected]; [email protected] Hong Sang [email protected] Wenqiang Wang [email protected] Chunmian Chen [email protected] 1
School of Mental Health, Jining Medical University, Jining 272119, Shandong Province, China
2
Psychiatric-Neuroimaging-Genetics Laboratory, Wenzhou Seventh People’s Hospital, Wenzhou 325000, Zhejiang Province, China
3
Psychiatric-Neuroimaging-Genetics-Comorbidity Laboratory, Tianjin Mental Health Centre, Tianjin Anding Hospital, Mental Health Teaching Hospital of Tianjin Medical University, Tianjin 300222, China
4
Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, China
5
MDT Center for Cognitive Impairment and Sleep Disorders, First Hospital of Shanxi Medical University, Taiyuan 030001, China
6
Department of Psychiatry, Changchun Sixth Hospital, Changchun 130052, Jilin Province, China
7
Co-collaboration Laboratory of China and Canada, Xiamen Xianyue Hospital and University of Alberta, Xiamen 361000, China
Keywords Auditory verbal hallucinations . Healthy individuals . Insight . Global functional connectivity density
Introduction According to the strictest criteria proposed by Johns (“Did you at any time hear voices saying quite a few words or sentences when there was no one around that might account for it?”), 0.7% of the general population have experienced auditory verbal hallucinations (AVH) (Beavan et al. 2011; Johns et al. 2004). Of those who have experienced AVH, ones who “did not have clinically defined delusions, disorganization, or negative or catatonic symptoms, nor did they meet criteria for clu
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