Signal transduction, receptors, mediators and genes: younger than ever - the 13th meeting of the Signal Transduction Soc
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Signal transduction, receptors, mediators and genes: younger than ever - the 13th meeting of the Signal Transduction Society focused on aging and immunology Frank Entschladen1*, Joachim Altschmied2, Ria Baumgrass3, Iris Behrmann4, Klaudia Giehl5, Heike Hermanns6, Otmar Huber7, Arnd Kieser8, Lars-Oliver Klotz2, Katharina F Kubatzky9, Ralf Hass10, Ottmar Janssen11, Karlheinz Friedrich7
Abstract The 13th meeting of the Signal Transduction Society was held in Weimar, from October 28 to 30, 2009. Special focus of the 2009 conference was “Aging and Senescence”, which was co-organized by the SFB 728 “Environmentally-Induced Aging Processes” of the University of Düsseldorf and the study group ‘Signal Transduction’ of the German Society for Cell Biology (DGZ). In addition, several other areas of signal transduction research were covered and supported by different consortia associated with the Signal Transduction Society including the long-term associated study groups of the German Society for Immunology and the Society for Biochemistry and Molecular Biology, and for instance the SFB/Transregio 52 “Transcriptional Programming of Individual T Cell Subsets” located in Würzburg, Mainz and Berlin. The different research areas that were introduced by outstanding keynote speakers attracted more than 250 scientists, showing the timeliness and relevance of the interdisciplinary concept and exchange of knowledge during the three days of the scientific program. This report gives an overview of the presentations of the conference. The scientific program of the 13th annual conference of the Signal Transduction Society started with a workshop on Immune Signaling that was co-organized by the study group ‘Signal Transduction” of the German Society for Immunology and The SFB/Transregio 52 “Transcriptional Programming of Individual T Cell Subsets” with scientists from Würzburg, Mainz and Berlin. The introductory keynote lecture was given by Arthur Weiss from the Howard Hughes Medical Institute in San Francisco, CA, the past president of the American Association of Immunology (AAI) and an outstanding pioneer of T cell signal transduction research. Professor Weiss discussed the requirements and properties of inhibitors of protein tyrosine kinases for their clinical use. In particular, he reported that certain inhibitors induce quite dramatic and relevant conformational changes in the key tyrosine kinase ZAP-70 that alter the * Correspondence: [email protected] 1 Institute of Immunology, Witten/Herdecke University, Germany
accessibility of the molecule and regulate the state of activation be fine-tuning intra- and intermolecular protein-protein interaction. Following the STS tradition, the workshop was continued by short presentations selected from the more than 120 submitted abstracts. Dirk Mielenz (University of Erlangen-Nuremberg) introduced Swiprosin-1/EFhd2, a scaffold protein that for example enables the recruitment of the Syk kinase and other signal transducers such as PLCg2 to B cell receptor associated lipid
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