Small Molecule Microarrays Methods and Protocols
Small molecule microarrays (SMM) were introduced in 1999 and within just a short span of time, have established themselves as a vibrant next generation platform for high-throughput screening. Small Molecule Microarrays: Methods and Protocols consolidates
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Mahesh Uttamchandani Shao Q. Yao Editors
Small Molecule Microarrays Methods and Protocols Second Edition
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Small Molecule Microarrays Methods and Protocols Second Edition
Edited by
Mahesh Uttamchandani DSO National Laboratories, Defence Medical and Environmental Research, Singapore, Singapore
Shao Q. Yao Department of Chemistry, Faculty of Science, National University of Singapore, Singapore, Singapore
Editors Mahesh Uttamchandani DSO National Laboratories Defence Medical and Environmental Research Singapore, Singapore
Shao Q. Yao Department of Chemistry Faculty of Science, National University of Singapore Singapore, Singapore
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-6582-3 ISBN 978-1-4939-6584-7 (eBook) DOI 10.1007/978-1-4939-6584-7 Library of Congress Control Number: 2016958616 © Springer Science+Business Media New York 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface Small Molecule Microarrays: Methods and Protocols showcases a cornucopia of ways in which small molecule microarray (SMM) technology may be deployed for multiplexed screening and discovery. SMMs were introduced one and a half decades ago in 1999 and, within a short space of time, have already established themselves as a vibrant and compelling platform for drug discovery, proteomics, glycomics, and sero-profiling. Significant developments have equipped practitioners with a variety of synthetic tools, immobilization methods, assay designs, and data processing/acquisition modes, hence propelling the SM
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