Study on Synthesis Chitosan Oligomer Stabilized Silver Nanoparticles Using Green Chemistry and Their Burn Wound Healing
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Study on Synthesis Chitosan Oligomer Stabilized Silver Nanoparticles Using Green Chemistry and Their Burn Wound Healing Effects Yun Ok Kang1 and Won Ho Park2 1
Department of Nano Technology, Chungnam National University, Daejeon, Korea
2
Department of Advanced Organic Materials and Textile System Engineering, Chungnam National University, Daejeon, Korea
ABSTRACT The preparation of metal nanoparticles is a major research area in technical engineering due to their unusual properties, such as catalytic activity, novel electronic, optic and magnetic properties and biotechnology. Specially, silver has been used for years in the medical field for antimicrobial applications because it known for its antimicrobial properties and even has shown to prevent HIV binding to host cells. Common synthesis, chemical and physical methods using chemical reducing agent and organic solvent are not too suitable to have application to bioengineering because they should have associated environmental toxicity or biological hazards. Development of sustainable processes through green chemistry is attractive about the elimination or minimization of chemical waste. Here, we introduce the green method for preparation of silver nanoparticles using chitosan oligomer as both reducing and stabilizing agent in water. We expect that the use of environmentally benign solvent and chitosan oligomer to prepare silver nanoparticles offers numerous benefits and compatibility for pharmaceutical and biomedical applications.
INTRODUCTION The application of nanoscale materials, usually ranging from 1 to 100 nanomerters (nm), is an emerging area of nanotechnology. Nanomaterials may provide solution to technological and environmental challenges in the areas of solar energy conversion, catalysis, medicine and water treatment. Generally, metal nanoparticles can be prepared and stabilized by physical and chemical methods such as chemical reduction, electrochemical techniques and photochemical reduction is most widely used. Most research reported these chemical and physical methods using chemical reducing agents and organic solvent are not too suitable to have application to biotechnology since they should have associated environmental toxicity or biological hazards. Over the past decade there has been an increased emphasis on the topic of “green” chemistry and chemical processes. These efforts aim at the total elimination or at least the minimization of generated waste, green synthesis is progressively integrating with modern developments in science and industry. Utilization of nontoxic chemicals, environmentally benign solvents and renewable materials are some of the key issues that merit important consideration in a green synthesis. In earlier reports natural polymers like starch and chitosan are reported to stabilize silver nanoparticles, separate reducing agents were used.
The antimicrobial properties of silver have been known from antiquity: the Egyptians, Greeks, Romans, and other ancient civilizations used silver vessels to store perishable foods, and s
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