Synthesis of Biocompatible Zinc Oxide (ZnO) Nanoparticles and Their Neuroprotective Effect of 6-OHDA Induced Neural Dama
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ORIGINAL PAPER
Synthesis of Biocompatible Zinc Oxide (ZnO) Nanoparticles and Their Neuroprotective Effect of 6-OHDA Induced Neural Damage in SH-SY 5Y Cells Xiyan Ding1 • Ke Lin2 • Yandong Li3 • Minyan Dang4 • Lijie Jiang5 Received: 24 October 2019 Springer Science+Business Media, LLC, part of Springer Nature 2019
Abstract Biocompatible zinc oxide nanoparticles were prepared using a simple co-precipitation method. Through this method, the synthesized zinc oxide nanoparticles that are of uniform size and highly crystalline in nature. The particle formation and stability were confirmed with UV–visible spectrometry and the functional groups which present in the particles were identified with FT-IR analysis. The particle size was confirmed with DLS analysis and the charges of the particles were determined by Zeta analysis. Particle size and shape were depicted from SEM analysis. The characterized particles were highly effective against the 6-OHDA induced cell damage in SH-SY5Y cells. The synthesized particles were found to be highly compatible to the selected cells. It recovers the neural cell damage at the concentration of 50 lg/mL. Our formulation thus can be used as an effective drug system for neurotherapy in near future Furthermore, it was found to be capable of inhibiting apoptotic activities in the selected SH-SY5Y cells thus it execute the damage recovery mechanism. Taken as a whole, our synthesized nanomaterials significantly recover the SH-SY5Y cells from 6-OHDA induced cell damage in in vitro system. Further evaluation should be needed to optimize the prepared nanomaterials as a candidate for treating various neural related diseases. Keywords Biocompatible Zinc oxide nanoparticles Neuroprotective effect SH-SY5Y cells
Introduction
Xiyan Ding and Ke Lin were equally shared the first authorship. & Lijie Jiang [email protected] 1
Beihua University, Jilin City 130021, Jilin, People’s Republic of China
2
ICU, University-Town Hospital of Chongqing Medical University, Chongqing 401331, People’s Republic of China
3
General Surgery Department 2, Beihua University Affiliated Hospital, Jilin City 130021, Jilin, People’s Republic of China
4
Innoscience Research SdnBhd, One City, Jalan, 47650 Subang Jaya, Selangor, Malaysia
5
Second Ward, Department of Neurology, Third People’s Hospital of Dalian City, Dalian 116000, Liaoning, People’s Republic of China
Nanotechnology deals with nanoparticles that are atomic or molecular aggregates characterized by size less than 100 nm. These are actually modified form of basic elements derived by altering their atomic as well as molecular properties of elements [1]. The application of nanotechnology in medical applications, commonly referred as ‘‘nanomedicine’’, seeks to deliver a new set of tools, devices and therapies for treatment of human disease. Nanomaterials that can act as biological mimetic, ‘‘nanomachines’’, biomaterials for tissue engineering, shape-memory polymers as molecular switches, biosensors, labo
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