Systems biology-based analysis implicates a novel role for vitamin D metabolism in the pathogenesis of age-related macul
- PDF / 672,297 Bytes
- 31 Pages / 609.449 x 790.866 pts Page_size
- 38 Downloads / 134 Views
Systems biology-based analysis implicates a novel role for vitamin D metabolism in the pathogenesis of age-related macular degeneration Margaux A. Morrison,1,2 Alexandra C. Silveira,1 Nancy Huynh,1 Gyungah Jun,3 Silvia E. Smith,2 Fani Zacharaki,4 Hajime Sato,1 Stephanie Loomis,1 Michael T. Andreoli,1 Scott M. Adams,1 Monte J. Radeke,5 Austin S. Jelcick,6 Yang Yuan,6 Aristoteles N. Tsiloulis,4 Dimitrios Z. Chatzoulis,4 Giuliana Silvestri,7 Maria G. Kotoula,4 Evangelia E. Tsironi,4 Bruce W. Hollis,8 Rui Chen,9 Neena B. Haider,6 Joan W. Miller,10 Lindsay A. Farrer,11 Gregory S. Hageman,2 Ivana K. Kim,10 Debra A. Schaumberg12 and Margaret M. DeAngelis1,2* 1
Ocular Molecular Genetics Institute, Harvard Medical School, Massachusetts Eye and Ear, Boston, MA, USA Department of Ophthalmology and Visual Sciences, University of Utah, Salt Lake City, UT, USA 3 Departments of Medicine (Section of Biomedical Genetics), Ophthalmology and Biostatistics, Boston University Schools of Medicine and Public Health, Boston, MA, USA 4 Department of Ophthalmology, University of Thessaly School of Medicine, Larissa, Greece 5 Center for the Study of Macular Degeneration, Neuroscience Research Institute, University of California, Santa Barbara, CA, USA 6 Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, USA 7 Centre for Vision and Vascular Science, Queen’s University, Belfast, UK 8 Pediatric Nutritional Sciences, Medical University of South Carolina, Charleston, SC, USA 9 Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA 10 Retina Service, Harvard Medical School, Massachusetts Eye and Ear, Boston, MA, USA 11 Departments of Medicine (Section of Biomedical Genetics), Ophthalmology and Biostatistics, Neurology, Epidemiology, Boston University Schools of Medicine and Public Health, Boston, MA, USA 12 Division of Preventive Medicine, Brigham and Women’s Hospital and the Department of Ophthalmology, Harvard Medical School, Boston, MA, USA *Correspondence to: Tel: þ1 801 213 4052; Fax: þ1 801 581 5335; E-mail: [email protected] 2
Date received (in revised form): 22 June 2011
Abstract Vitamin D has been shown to have anti-angiogenic properties and to play a protective role in several types of cancer, including breast, prostate and cutaneous melanoma. Similarly, vitamin D levels have been shown to be protective for risk of a number of conditions, including cardiovascular disease and chronic kidney disease, as well as numerous autoimmune disorders such as multiple sclerosis, inflammatory bowel diseases and type 1 diabetes mellitus. A study performed by Parekh et al. was the first to suggest a role for vitamin D in age-related macular degeneration (AMD) and showed a correlation between reduced serum vitamin D levels and risk for early AMD. Based on this study and the protective role of vitamin D in diseases with similar pathophysiology to AMD, we examined the role of vitamin D in a family-based cohort of 481 sibling pairs. Using extremely phenotypically
Data Loading...
