Two-Dimensional Ultrathin Multilayers ZIF-8 Nanosheets with Sustained Antibacterial Efficacy for Aeromonas Hydrophila
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Two‑Dimensional Ultrathin Multilayers ZIF‑8 Nanosheets with Sustained Antibacterial Efficacy for Aeromonas Hydrophila Xiuxia Wei1 · Dongpo Xu1 · Kangjie Ge1 · Shuyan Qi1 · Yan Chen1 Received: 19 February 2020 / Accepted: 23 March 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract In this study, a simple and efficient strategy with bola-form template to construct the two-dimensional ultrathin multilayers ZIF-8 nanosheets was developed, the nanosheet was used as antibacterial for Aeromonas hydrophila (A. hydrophila) for the first time. It shows the obviously lamellar structure with eleven ZIF-8 lamellar crystal layers uniformly distributed in each nanosheet, the thickness of the whole nanosheet is approximately 36 nm, and the distance between the two adjacent layers is approximately 3.6 nm. It has the high antibacterial efficacy for A. hydrophila, which can be killed within 8 h. Keywords Antibacterial efficacy · Aeromonas hydrophila · Ultrathin multilayers nanosheets · ZIF-8
1 Introduction A. hydrophila isolated from fresh water ponds is a ubiquitous gram-negative motile rod-shaped bacterium as an emerging pathogen among cultured fishes [1]. It can produce many different putative virulence factors like cytotoxin, enterotoxin, hemolysin, cytotonic enterotoxin, outer membrane proteins and enzymes such as lipases, DNases, elastase and gelatinase [2]. It has been reported that A. hydrophila can cause severe infections in immune-compromised patients [3]. Therefore, it is particularly important to inhibit the growth of A. hydrophila especially for the aquaculture industry. Many materials have been reported used for the antibacterial, such as the metal ions [4–7], antimicrobial peptide [8] and metal oxides [9–11]. However, these materials agents have the drawback of product break-down and lack of long-term stability especially for the A. hydrophila in aquaculture [12].Metal–organic frameworks (MOFs) as a new class of inorganic–organic hybrid materials have been applied in diverse fields,such as sensor [13], drug delivery [14], gas storage and separation [15, 16], conduction [17] Xiuxia Wei and Dongpo Xu contributed equally in this work. * Dongpo Xu [email protected] 1
School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, People’s Republic of China
and adsorption [18], etc. MOFs was also used as antibacterials, compared with the traditional chemical antibacterial agents, MOFs consist of metallic centers and organic ligands linked through coordination bonds as the antibacterial agents have many advantages in long-term persistence, high effectiveness, metal release control and especially the wide antibacterial spectrum [19–26]. MOFs with silver [21, 22], copper [23] and cobalt [20] as metal have been applied in the antibacterial, in different with the other metals, zinc is an inexpensive non-toxic d-block metal, and more recently, zinc based MOFs showing biocide properties against S. aureus and S. epidermidis [24]. The s
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