Umbilical Cord Blood Banking and Transplantation
This comprehensive volume discusses the current scope of umbilical cord blood transplantation (UCBT), including recent controversies and future developments for improving clinical outcomes. Its twenty chapters introduce new applications in regenerative me
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Series Editor Kursad Turksen, Ph.D. [email protected]
For further volumes: http://www.springer.com/series/7896
Karen Ballen Editor
Umbilical Cord Blood Banking and Transplantation
Editor Karen Ballen Leukemia Program Massachusetts General Hospital Harvard Medical School Boston, Massachusetts USA
ISSN 2196-8985 ISSN 2196-8993 (electronic) ISBN 978-3-319-06443-7 ISBN 978-3-319-06444-4 (eBook) DOI 10.1007/978-3-319-06444-4 Springer Cham Heidelberg New York Dordrecht London Library of Congress Control Number: 2014939453 © Springer International Publishing Switzerland 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is a brand of Springer Springer is part of Springer Science + Business Media (www.springer.com)
Preface
The first transplantation using umbilical cord blood (UCB) was performed in 1989; the transplant was performed with an international collaboration led by Dr. Eliane Gluckman and colleagues in Paris for a child with Fanconi anemia. Since then, over 30,000 umbilical cord blood transplantations (UCBT) have been performed worldwide, and over 600,000 UCB units have been donated for public use. The first UCBT were given to children, but with a better understanding of the importance of cell dose, UCBT were extended to adults. UCB is an important graft source for the seventy percent of patients who do
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