A Multi-strain Potential Probiotic Formulation of GABA-Producing Lactobacillus plantarum 90sk and Bifidobacterium adoles
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A Multi-strain Potential Probiotic Formulation of GABA-Producing Lactobacillus plantarum 90sk and Bifidobacterium adolescentis 150 with Antidepressant Effects R. A. Yunes 1 & E. U. Poluektova 1 & E. V. Vasileva 2 & M. V. Odorskaya 1 & M. V. Marsova 1 & G. I. Kovalev 2 & V. N. Danilenko 1
# Springer Science+Business Media, LLC, part of Springer Nature 2019
Abstract Today, a number of studies conclusively show that certain bacterial strains, mainly from the genera Lactobacillus and Bifidobacterium, influence the functioning of the central nervous system, leading to changes in beahvior, nociception and the cognitive abilities of humans and animals. Such strains serve as the basis for developing probiotics with a curative potential for the central nervous system — psychobioitcs. However, the question of how to find such strains and which criteria to use for their selection remains unanswered. Some compounds produced by bacteria, such as gamma-aminobutyric acid (GABA), the main inhibitory neurotransmitter of the central nervous system, are potential mediators between bacterial cells and the host. Previously, we established that some species of Lactobacillus and Bifidobacterium are capable of producing GABA. We presumed that GABA-producing Lactobacillus and Bifidobacterium strains are great candidates to use as psychobiotics. Therefore, we selected the strains Lactobacillus plantarum 90sk and Bifidobacterium adolescentis 150 as efficient GABA producers. The goal of this work was to assess the probiotic properties of the selected strains as well as their antidepressive effects in mice. We established that the ingestion of the probiotic composition based on the selected strains by BALB/c mice for 2 weeks reduced depressive-like behavior in the forced swimming test; the effect was similar to that of fluoxetine. Keywords Lactobacillus . Bifidobacterium . Gamma-aminobutiric acid . Multi-strains probiotic composition . Antidepressant
Introduction The gut microbiota influences overall homeostasis of the macroorganism and plays an important role in the onset and development of several diseases: inflammatory diseases of both gastro-intestinal and urogenital tracts, metabolic disorders, and autoimmune diseases [1]. Probiotics based on certain bacteria are used today in combination with drugs to treat inflammatory diseases [2]. Over recent years, enough data emerged showing that certain bacterial Electronic supplementary material The online version of this article (https://doi.org/10.1007/s12602-019-09601-1) contains supplementary material, which is available to authorized users. * R. A. Yunes [email protected] 1
Vavilov Institute of General Genetics Russian Academy of Sciences, Moscow Russian Federation
2
Federal State Budgetary Institution “Research Zakusov Institute of Pharmacology”, Moscow Russian Federation
strains, mainly lactobacilli and bifidobacteria, influence the functioning of the central nervous system (CNS), behavior, nociception, and cognitive function of humans and animals. Bacteria influence the CNS via t
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