Alendronic acid
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Osteonecrosis of the jaw in an elderly patient, treated with teriparatide: case report An 88-year-old woman presented with a 12-month history of suppuration, pain, and an unhealed mandibular socket following tooth extraction. Imaging showed left mandible necrosis consistent with a diagnosis of osteonecrosis of the jaw. She had started receiving alendronic acid 70mg/week following a hip fracture that occurred 10 years earlier [route not stated; duration of treatment to reaction onset not clearly stated]. She consented to off-label treatment with SC teriparatide 20 µg/day; her symptoms resolved after 8 weeks, with healing of her osteonecrosis. Cheung A, et al. Teriparatide therapy for alendronate-associated osteonecrosis of the jaw. New England Journal of Medicine 363: 2473-2474, No. 25, 16 Dec 2010. Available from: URL: http://dx.doi.org/10.1056/nejmc1002684 803048366 Australia
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Reactions 22 Jan 2011 No. 1335
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