Alendronic acid
- PDF / 122,929 Bytes
- 1 Pages / 623.591 x 841.847 pts Page_size
- 29 Downloads / 189 Views
1
Alendronic acid Skin eruption: case report A 60-year-old woman developed a cutaneous skin eruption during treatment with alendronic acid for osteoporosis. The woman developed maculopapular skin lesions on head and neck after 4 months of therapy with alendronic acid 10 mg/day. Histological examination revealed superficial perivascular spongiotic dermatitis with focal vacuolisation of the basal cell layer; there also was a mixed cellular infiltrate of neutrophils and eosinophils. Alendronic acid was discontinued and, within 6 weeks, the woman’s skin eruption spontaneously resolved with only residual scaling. Scratch chamber patch testing with 50% alendronic acid in water or petrolatum showed crescendo reactions at days 2 and 3. Open rub, prick and scratch tests were negative; weak positive skin reaction to different alendronic acid concentrations were also observed in bisphosphonate-naive control subjects. The woman was rechallenged with oral alendronic acid 2 months after complete remission. After 3 months of receiving alendronic acid 10 mg/day, her skin reaction recurred. Alendronic acid was discontinued and topical treatment with a corticosteroid ointment was started. Her skin lesions resolved within 2 weeks. She then started receiving risedronic acid without occurrence of any adverse effects. Brinkmeier T, et al. Adverse cutaneous drug reaction to alendronate. Contact 801091095 Dermatitis 57: 123-125, No. 2, Aug 2007 - Germany
0114-9954/10/1162-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 28 Jul 2007 No. 1162
Data Loading...
