Aripiprazole
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Aripiprazole Pisa syndrome: case report
A 48-year-old man developed Pisa syndrome while receiving treatment with aripiprazole for schizophrenia. The man, who had schizophrenia, was hospitalized for severe psychotic agitation on 03 October. He started receiving oral clozapine. However, only partial response was noted. Hence, paliperidone was added to his therapy. Over the following weeks, paliperidone was discontinued on 7 November and he started receiving aripiprazole 5mg on 09 November, which was titrated up to 15mg by 15 November [route not stated]. On 15 November, he began complaining of right-sided non-radiating lower back pain, which exacerbated by movement. He was noted to be leaning to the left at about 15°. Physical examination showed tightened rightsided paraspinal muscle, with no point tenderness The man was treated with lorazepam and muscles spasm was resolved. He was treated with paracetamol for pain. He suspected to have Pisa syndrome. Aripiprazole was tapered. He was continued to have flank pain and lateral truncal flexion on 20 November. He was treated with benzatropine. By 23 November, aripiprazole was discontinued. By the following week, his left-sided upper body flexion had improved significantly, and he was able to maintain upright posture while ambulating. Smith C, et al. Pisa Syndrome and Aripiprazole. Journal of Clinical Psychopharmacology 40: 99-101, No. 1, Jan 2020. Available from: URL: http://doi.org/10.1097/ JCP.0000000000001162
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Reactions 14 Nov 2020 No. 1830
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