Cell Migration Developmental Methods and Protocols
Cell migration is a key component of many biological processes including embryonic development, immune responses, wound healing, organ regeneration, and cancer cell metastasis, thus making it an exciting and crucial field of study. The aim of Cell M
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Molecular Biology™
Series Editor John M. Walker School of Life Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Cell Migration Developmental Methods and Protocols
Second Edition
Edited by
Claire M. Wells Division of Cancer Studies, King’s College London, London, UK
Maddy Parsons Randall Division of Cell and Molecular Biophysics, King’s College London, London, UK
Editors Claire M. Wells, Ph.D Division of Cancer Studies King’s College London London, UK [email protected]
Maddy Parsons Randall Division of Cell and Molecular Biophysics King’s College London London, UK [email protected]
Please note that additional material for this book can be downloaded from http://extras.springer.com ISSN 1064-3745 e-ISSN 1940-6029 ISBN 978-1-61779-206-9 e-ISBN 978-1-61779-207-6 DOI 10.1007/978-1-61779-207-6 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011931279 © Springer Science+Business Media, LLC 2011 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Preface Cell migration is a key component of many biological processes, including embryonic development, immune responses, wound healing, organ regeneration, and cancer cell metastasis. Such cell movements can involve migration of individual cells or groups of cells, or the movement of large sheets of conjoined cells. Researchers have spent many years unravelling the highly complex molecular mechanisms involved in the initiation and maintenance of migration using a range of biochemical and functional assay systems. Furthermore, as the study of cell migration is an intrinsically visual science, recent efforts have also focused on the development of microscopy techniques to precisely define the contribution of specific signalling pathways to different aspects of motility. Considerable advances have been made in our understanding of the cellular machinery that drives cell movement, the signalling pathways involved, and how these may be regulated to achieve specific modes of migration in different contexts. Recently, much of this work has been driven by the use of RNAi technology and the expression of fluorescently tagged proteins. Moreover, large-scale s
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