Cell Polarity 2 Role in Development and Disease
This work provides a state-of-the art overview on the most relevant aspects of cell polarity.Volume 2 discusses the physiological and pathophysiological relevance of cell polarity. It especially focuses on pathophysiological conditions in which one or sev
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Cell Polarity 2
Role in Development and Disease
Cell Polarity 2
.
Klaus Ebnet Editor
Cell Polarity 2 Role in Development and Disease
Editor Klaus Ebnet Institute-associated Research Group “Cell Adhesion and Cell Polarity” Institute of Medical Biochemistry Center for Molecular Biology of Inflammation (ZMBE) University Mu¨nster Mu¨nster Germany
ISBN 978-3-319-14465-8 ISBN 978-3-319-14466-5 DOI 10.1007/978-3-319-14466-5
(eBook)
Library of Congress Control Number: 00703242 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com)
Preface
Cell polarity refers to an asymmetric distribution of proteins, lipids, or RNA in the cell. Most animal cells are polarized. In many cell types, polarity is morphologically visible. Neurons, for example, contain a single, long axon and multiple, short dendrites. Migrating fibroblasts protrude multiple lamellipodia selectively at the leading edge. In other cases, cell polarity manifests itself at the molecular and functional level. Stem cells divide asymmetrically by unequally partitioning cell fate determinants into the two daughter cells thus generating daughter cells with different cell fates. Epithelial cells contain two different membrane compartments characterized by a different molecular composition and different functions. Cellular polarization is a highly dynamic process, and the ability of individual cells to polarize is required for the early development of the zygote and for the generation of functional organs. It is not surprising that a loss of the ability of cells to develop and/or maintain a polarized state results in developmental defects and promotes tumor formation. Given the many facets of cellular polarization in different cell types and tissues, it is a central question how this div
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