Cisplatin
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Cisplatin Posterior reversible encephalopathy syndrome: case report
A 46-year-old woman who developed posterior reversible encephalopathy syndrome during treatment with cisplatin for colon cancer. The woman was hospitalised with aphasia, repeated vomiting, and right upper limb weakness since 12h. She had colon cancer for which she had undergone a surgery 5 months prior, and had been receiving chemotherapy with cisplatin [dosage and route not stated]. Eight days prior to the admission, she had received the eight cycle of cisplatin. At admission, her vitals, CNS examination and other investigations were normal. However, a brain MRI revealed restricted diffusion in bilateral cerebral white matter including corpus callosum, posterior limb of internal capsule and centrum semiovale. The findings indicated chemotherapy-related neurotoxicity. A diagnosis of cisplatin-induced posterior reversible encephalopathy syndrome was made. The woman was treated with levetiracetam, mannitol and dexamethasone, after which her aphasia resolved. However, on the next day evening, she again experienced focal convulsions and aphasia. She was then treated with fosphenytoin, and the previous medications were continued. Subsequently, her aphasia resolved. Two days later, a brain MRI revealed complete resolution of white matter abnormalities. Her aphasia and right upper limb grip also recovered completely. She had no further episodes of convulsion. Admane SS, et al. A case of posterior reversible encephalopathy syndrome mimicking stroke. Indian Journal of Critical Care Medicine 24: 877-878, No. 9, Sep 2020. Available from: URL: http://doi.org/10.5005/jp-journals-10071-23588
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Reactions 14 Nov 2020 No. 1830
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