Cisplatin
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Cisplatin Hypomagnesaemia and hypocalcaemia: case report
A 71-year-old man developed hypomagnesaemia and hypocalcaemia during treatment with cisplatin for limited-stage small-cell lung cancer. The man, who was recently diagnosed with limited-stage small-cell lung cancer, started receiving radiation therapy and chemotherapy with cisplatin [dosage and route not stated] along with etoposide. He had no prior history of calcium disorders or any endocrinopathies. Subsequently, he developed cisplatin therapy related hypomagnesaemia and hypocalcaemia [time to reaction onset not stated]. Therefore, the man was started on unspecified home supplements for both the hypomagnesaemia and hypocalcaemia. One week after completion of the third chemotherapy cycle, he presented to hospital due to numbness in hands, feet and area around the mouth. He also reported painful calf and hand contractures, and spasms, but denied chest pain, shortness of breath or palpitations. Physical examination showed a positive Trousseau sign. Hyper-reflexia was also noted in both the upper and lower extremities. Clinical examination revealed the following: undetectable magnesium level, calcium level of 6.0 mg/dL, albumin-corrected calcium level of 6.6 mg/dL, albumin level of 3.2 mg/dL, ionised calcium level of 0.62 mg/dL, normal vitamin-D level and elevated parathyroid hormone level 128 pg/mL (indicative of parathyroid hormone resistance). Subsequently, he was hospitalised, and his treatment was started with IV magnesium and IV calcium supplements. Later, as the calcium level improved to 6.7 mg/dL (without albumin correction) and the magnesium level improved to 1.7 mg/dL, he was discharged on oral calcium carbonate and oral magnesium oxide. Puchalski AR, et al. PARATHYROID HORMONE RESISTANCE FROM SEVERE HYPOMAGNESEMIA CAUSED BY CISPLATIN. Endokrynologia Polska : no pagination, 18 Sep 2020. Available from: URL: http://doi.org/10.5603/EP.a2020.0061
0114-9954/20/1826-0001/$14.95 Adis © 2020 Springer Nature Switzerland AG. All rights reserved
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Reactions 17 Oct 2020 No. 1826
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