Clinical Metabolomics Methods and Protocols
This detailed volume presents a comprehensive compendium of clinical metabolomics protocols covering LC-MS, GC-MS, CE-MS, and NMR-based clinical metabolomics as well as bioinformatics and study design considerations. The methodologies explored here form t
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Martin Giera Editor
Clinical Metabolomics Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Clinical Metabolomics Methods and Protocols
Edited by
Martin Giera Center for Proteomics and Metabolomics, Leiden University Medical Center Leiden, The Netherlands
Editor Martin Giera Center for Proteomics and Metabolomics Leiden University Medical Center Leiden, The Netherlands
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-7591-4 ISBN 978-1-4939-7592-1 (eBook) https://doi.org/10.1007/978-1-4939-7592-1 Library of Congress Control Number: 2017963765 © Springer Science+Business Media, LLC 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Cover illustration: Cover art design by Dr. Magnus Palmblad Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media, LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface In recent years, metabolomics has become an inevitable tool in several clinical research fields, helping to discover new diagnostic markers and molecules and furthering our understanding of pathophysiological processes. Unlike the field of clinical chemistry which today is integrated into many clinical processes, clinical metabolomics is a much more “juvenile” discipline still on its way to become fully integrated into modern health care. Nevertheless, metabolomics is at the core of several very promising initiatives evolving around personalized health care and precision medicine. Ideally, clinical metabolomics should be seen as a complimentary discipline to clinical chemistry. The much more hypothesis
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