Cytotoxicity and antimicrobial efficiency of selenium nanoparticles biosynthesized by Spirulina platensis
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ORIGINAL PAPER
Cytotoxicity and antimicrobial efficiency of selenium nanoparticles biosynthesized by Spirulina platensis Heba S. Abbas1 · Doha H. Abou Baker2 · Entesar A. Ahmed3 Received: 21 June 2020 / Revised: 29 August 2020 / Accepted: 12 September 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Nanotechnology has been exploited as a great scientific area especially in stating scenarios in drug discovery. In the present study, biosynthesized selenium nanoparticles (SeNPs) were prepared by the filtrate of Spirulina platensis after ultrasonication of their biomass. The biosynthesized SeNPs was characterized by using ultra-violet visible, Fourier transform infra-red spectroscopy, dynamic light scattering, and transmission electron microscope (TEM). The zeta potential of Biogenic SeNPs was -32.9 ± 8.12 mv that caused their stability. TEM micrographs elucidated the spherical shape of Biogenic SeNPs with a mean average size of 79.40 ± 44.26 nm. Biogenic SeNPs showed potential antimicrobial activity against gram-negative bacteria and yeast fungi C. albicans ATCC10231. No toxic effect was observed for SeNPs on normal kidney and liver cell lines. Biogenic SeNPs could be considered as a hopeful choice for future therapeutic applications because of their good biocompatibility and reactivity. Keywords Green nanotechnology · Spirulina platensis · Biogenic SeNPs · Antimicrobial · Cytotoxicity
Introduction Selenium element (Se) has attracted a lot of attention because of its great importance in medicine (Xu et al. 2018). Se is a major constituent of several enzymes, such as glutathione peroxidase (GPx), thioredoxin reductase (TRx), and deiodinases. These enzymes have essential role in many processes as antioxidant activity improving muscle function and cancer prevention (Mehdi et al. 2013). Se is used in many industries. In the agricultural industry it acts as a fertilizer, in electronic industry it participates in photoelectric cells and glass manufacturing, and in painting industry it enters in formation of pigments. It is also used in pharmaceutical Communicated by Erko stackebrandt. * Doha H. Abou Baker [email protected] 1
Microbiology Department, National Organization for Drug Control and Research (NODCAR), Giza, Egypt
2
Medicinal and Aromatic Plants Dept, Pharmaceutical and Drug Industries Division, National Research Centre, Cairo, Egypt
3
Botany and Microbiology Department, Faculty of Science (Girl Branch), Al‑Azhar university, Cairo, Egypt
industry as antifungal agent in shampoos for curing dry scalp and as nutrient supplement (antioxidant) along with medicines (Chhabria and Desai 2016). Se persists in inorganic and organic forms, such as sodium selenite, Se chloride, selenomethionine, and selenocysteine (Rayman 2000). Nanomaterials at 1–100 nm scale exhibit unique characteristic properties such as chemical, optical and magnetic properties that are unlike their bulk metal properties (Jonathan et al. 2007). SeNPs have been employed in medical applications as antimicro
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