Effects of oral florfenicol on intestinal structure, function and microbiota in mice
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ORIGINAL PAPER
Effects of oral florfenicol on intestinal structure, function and microbiota in mice Shiyu Yun1,2 · Yurong Guo1 · Lan Yang1 · Xin Zhang2 · Weiqi Shen1 · Zhuo Wang1 · Shuang Wen1 · Dongdong Zhao1 · Haiping Wu1 · Jia Chen1 · Yaogui Sun1 · Zhibian Duan1 Received: 17 February 2019 / Revised: 27 August 2019 / Accepted: 13 September 2019 © Springer-Verlag GmbH Germany, part of Springer Nature 2019
Abstract Many kinds of antibiotics have effects on intestinal structure and function. In the current experimental study, we evaluate the effect of oral florfenicol on intestinal barrier in mice. Thirty adult male mice were randomly divided into two groups, the group none (N) and the group florfenicol (F), the mice in group F were orally administered florfenicol 100 mg/kg body weight (BW) for 7 days. At day 8, mice were euthanized and sampled for the analysis of alterations in genes and proteins from jejunum, jejunum morphology and microbiota analysis. Administration of florfenicol caused higher liver index (P
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