Helicobacter pylori Vacuolating Cytotoxin: Cell Intoxication and Anion-Specific Channel Activity
The entire sequence of the circular genome of two Helicobacter pylori strains is presently available (Tomb et al. 1997; Alm et al. 1999), together with portions of the genome of several other strains. These genomes are predicted to contain about 1,500 cod
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Editors R.W. Compans, Atlanta/Georgia M. Cooper, Birmingham/Alabama· Y. Ito, Kyoto H. Koprowski, Philadelphia/Pennsylvania· F. Melchers, Basel M. Oldstone, La Jolla/California· S. Olsnes, Oslo M. Potter, Bethesda/Maryland P.K. Vogt, La Jolla/California· H. Wagner, Munich
Springer Berlin Heidelberg New York Barcelona Hong Kong London Milan Paris Singapore Tokyo
Pore-Forming Toxins Edited by F. Gisou van der Goat
With 19 Figures and 1 Table
,
Springer
Professor
F.
Grsou VAN DER GOaT
Departement de Biochimie Sciences
1211
II,
Quai Ernest-Ansermet
Geneve
4
Switzerland E-mail: [email protected]
Cover Illustration: Ribbon representation of the staphylococcal (Xtoxin monomer when extractedfrom the tridimensional structure of heptamer (Song L et al., Science 1996, 274:1859-1866). The protruding p-hairpin takes part of the transmembrane p-barrel, thus forming the pore. (Figure by G. Prevost on the basis of the figure by Song et al. 1996 Science 274:1859-1866) ISSN ISBN
0070-217X 3-540-41386-3
Springer-Verlag Berlin Heidelberg New
York
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Preface
This book attempts for the first time to combine into one volume our current knowledge about some of the best-understood, protein pore-forming bacterial toxins. These fascinating molecules have the intrinsic capacity of existing as two normally incompatible forms, i.e., a fully soluble form and a transmembrane form. How these proteins undergo the metamorphosis between the first and the latter form has been the subject of intense research over the last decades. A combinat
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