In vitro study of aripiprazole loading and releasing efficiency of SBA-16
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In vitro study of aripiprazole loading and releasing efficiency of SBA16 Atul Kumar1 · Narender Ranga1 · Surender Duhan1,2 · Rajesh Thakur3 Received: 30 December 2019 / Accepted: 28 May 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Mesoporous silica (SBA-16) was synthesized by the hydrothermal synthesis route. The structural properties of the synthesized SBA-16 were found out by a small-angle X-ray diffraction technique. Morphological characterization was characterized by scanning electron microscope (SEM) and high-resolution transmission electron microscope (HRTEM). Nitrogen adsorption–desorption isotherm was used to find out surface area, pore size, and pore volume. Aripiprazole was used as a model drug to calculate drug loading efficiency of prepared SBA-16 and their release kinetics was also calculated with the response to three different pH solutions. UV–Visible spectrophotometer was used to find out the absorbance of the sample. The results indicated that the synthesized SBA-16 has high drug loading efficiency with a control release profile. Keywords Aripiprazole · SBA-16 · Mesoporous · Drug loading · Drug release
1 Introduction In recent researches, it is found that polymers are structurally and thermally not stable to carry the drug. Some polymers are toxic [1], that’s why they may be responsible to cause adverse effects in the body of living organisms. Polymers show slow biological degradation hence can be responsible for long term environmental pollution. To overcome all the drawbacks of polymer-based drug delivery there is a need to find out alternatives to conventional drug delivery vehicles. SBA-16 (Santa Barbara Amorphous-16) belongs to MCM-48 (Mobil Composition of Matter 48) family and is mesoporous silica with cubic symmetry, high surface to volume ratio, pore size, and pore volume can be modified accordingly. In the past decades, SBA-16 and other mesoporous silica attracted the researchers of various disciplines. SBA-16 used in variety of applications such as catalyst [2], molecular imaging [3], chromatography [4], * Surender Duhan [email protected] 1
Department of Materials Science and Nanotechnology, DCRUST, Murthal, Sonipat 131027, India
2
Department of Physics, DCRUST, Murthal, Sonipat 131027, India
3
Department of Bio and Nano Technology, GJUS&T, Hisar, Haryana 125001, India
drug delivery [5] etc. SBA-16 is a three-dimensional cubic mesoporous with high thermal, chemical and physical stability. The size of SBA-16 can be tuned from 50 nm to submicron scale [6] as well as its pore size [7] depending upon the application. The surface area of SBA-16 can be modified [8] to introduce large amount of molecule for a wide variety of applications. SBA-16 does not show any cellular toxicity [9] and also has no adverse effect on the environment therefore it does not cause any type pollution. Mesoporous silica is biocompatible and is removed from the body through urine through basic metabolic process of life [10]. Moreover mesoporous silica especi
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