Levofloxacin
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Anaphylaxis: case report A 27-year-old woman received the first dose of oral levofloxacin treatment [dosage not stated] for bronchitis. Twenty minutes later, she developed an anaphylactic reaction with acute laryngeal oedema, dyspnoea, dysphonia, tachycardia (180 beats/min), severe hypotension (systolic BP 40mm Hg), facial angioedema and generalised urticaria. Subsequently, strongly positive reactions were observed for a skin prick test with levofloxacin, and intradermal tests with ofloxacin 1/100 and pefloxacin 1/1000. [Patient treatment and outcome not stated.] Author comment: "[T]he diagnosis of Allergic Immediate Hypersensitivity Reaction is supported by the clinically relevant positivity of Prick tests." Caboni S, et al. Anaphylactic shock to levofloxacin with cross reactivity to other fluoroquinolons. Allergy 62 (Suppl. 83): 532 abstr. 1547, 2007 [abstract] 801104958 France
0114-9954/10/1194-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 22 Mar 2008 No. 1194
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