Levofloxacin
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Pseudotumour cerebri syndrome: case report An 18-year-old man received oral levofloxacin 500mg (two capsules daily) for broncho-pneumonia which was unresolved after 7 days of amoxicillin treatment. He developed tinnitus in his left ear, blurred vision, photophobia, headache and intermittent horizontal diplopia and vomiting 5 days later. His visual acuity was 9/10 in both eyes and ocular motility exam revealed palsy of his left VI cranial nerve. Marked bilateral papilloedema with some flame-shaped haemorrhages were seen during fundus oculi examination. Perimetry indicated enlargement of his blind spot. Lumbar puncture revealed raised opening pressure of 41cm of CSF. Levofloxacin was withdrawn 2 days after lumbar puncture. His symptoms resolved completely 2 weeks later. Author comment: "[T]he quick resolution of the headache, blurry vision, papilloedema, and diplopia after stopping levofloxacin intake supports a causal relationship between this antibiotic and intracranial hypertension, although a beneficial effect of the lumbar puncture cannot be ruled out." Cellini M, et al. Pseudotumour cerebri syndrome and levofloxacin therapy: A case report. Neuro-Ophthalmology 34: 358-360, No. 5-6, Dec 2010. Available from: 803043932 URL: http://dx.doi.org/10.3109/01658107.2010.499524 - Italy
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Reactions 27 Nov 2010 No. 1329
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