Microarrays Preparation, Microfluidics, Detection Methods, and Biolo
The area of microarrays has evolved from genomics, and has been applied to proteomics and single cell studies as well. The applications of microarrays benefit diverse fields ranging from fundamental systems biology to practical diagnostic tests. This book
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Integrated Analytical Systems Series Editor: Radislav A. Potyailo GE Global Research Center Niskayana, NY
For other titles published in this series, go to www.springer.com/series/7427
Kilian Dill • Robin Hui Liu • Piotr Grodzinski Editors
Microarrays Preparation, Microfluidics, Detection Methods, and Biological Applications
Editors Dr. Kilian Dill CombiMatrix Corporation, Inc. 6500 Harbour Heights Parkway Suite 301, Mukilteo, WA 98275 USA [email protected]
Dr. Robin Hui Liu Osmetech Molecular Diagnostics 757 S. Raymond Ave. Pasadena, CA 91105 USA [email protected]
Dr. Piotr Grodzinski National Institutes of Health National Cancer Institute 31 Center Drive Bethesda, MD 20892 USA [email protected]
ISBN: 978-0-387-72716-5 e-ISBN: 978-0-387-72719-6 DOI: 10.1007/978-0-387-72719-6 Library of Congress Control Number: 2008937468 © Springer Science+Business Media, LLC 2009 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper springer.com
Series Preface
In my career I’ve found that “thinking outside the box” works better if I know what’s “inside the box.” Dave Grusin, composer and jazz musician Different people think in different time frames: scientists think in decades, engineers think in years, and investors think in quarters. Stan Williams, Director of Quantum Science Research, Hewlett Packard Laboratories Everything can be made smaller, never mind physics; Everything can be made more efficient, never mind thermodynamics; Everything will be more expensive, never mind common sense. Tomas Hirschfeld, pioneer of industrial spectroscopy
Integrated Analytical Systems Series Editor: Dr. Radislav A. Potyrailo, GE Global Research, Niskayuna, NY The book series Integrated Analytical Systems offers the most recent advances in all key aspects of development and application of modern instrumentation for chemical and biological analysis. The key development aspects include: (i) innovations in sample introduction through micro- and nanofluidic designs, (ii) new types and methods of fabrication of physical transducers and ion detectors, (iii) materials for sensors that became available due to the breakthroughs in biology, combinatorial materials science, and nanotechnology, and (iv) innovative data processing and mining methodologies that provide dramatically reduced rates of false alarms. A multidisciplinary effort is
