Modified Nucleic Acids
This book spans diverse aspects of modified nucleic acids, from chemical synthesis and spectroscopy to in vivo applications, and highlights studies on chemical modifications of the backbone and nucleobases.Topics discussed include fluorescent pyrimidine a
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Kazuhiko Nakatani Yitzhak Tor Editors
Modified Nucleic Acids
Nucleic Acids and Molecular Biology
Volume 31
Series editor Janusz M. Bujinicki International Institute of Molecular and Cell Biology Laboratory of Bioinformatics and Protein Engineering Trojdena 4 02-109 Warsaw Poland
More information about this series at http://www.springer.com/series/881
Kazuhiko Nakatani • Yitzhak Tor Editors
Modified Nucleic Acids
Editors Kazuhiko Nakatani The Institute of Scientific and Industrial Research Osaka University Ibaraki, Osaka Japan
Yitzhak Tor University of California, San Diego La Jolla California USA
ISSN 0933-1891 ISSN 1869-2486 (electronic) Nucleic Acids and Molecular Biology ISBN 978-3-319-27109-5 ISBN 978-3-319-27111-8 (eBook) DOI 10.1007/978-3-319-27111-8 Library of Congress Control Number: 2015960936 © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland
Preface
Modified nucleosides, nucleotides, and oligonucleotides have become a mainstay of modern science. Used as biochemical and biophysical tools, as well as actual drugs and key component of discovery assays, one cannot but appreciate the impact such synthetic analogs have had on chemistry, biology, and medicine over the past several decades. With this backdrop in mind, we have put together this edited volume to honor Professor Isao Saito and celebrate his recent retirement, which also provided us with the opportunity to share some of his contributions with the community. For those of us who operate in the exciting field of modified nucleic acids, Professor Saito needs no introduction. For the benefit of the younger readers, we very briefly highlight some of his interests. Trained as a synthetic chemist, Professor Saito turned his attention to biological problems early in his career, as the field focusing
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