Non-Natural Nucleic Acids Methods and Protocols
This volume provides relevant synthetic strategies, incorporation, and applications of non-natural nucleic acids. Chapters detail monomer synthesis, oligomer synthesis/construction, and applications allowing researchers to explore and determine which meth
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Nathaniel Shank Editor
Non-Natural Nucleic Acids Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Non-Natural Nucleic Acids Methods and Protocols
Edited by
Nathaniel Shank Department of Chemistry and Biochemistry, Georgia Southern University, Savannah, GA, USA
Editor Nathaniel Shank Department of Chemistry and Biochemistry Georgia Southern University Savannah, GA, USA
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-9215-7 ISBN 978-1-4939-9216-4 (eBook) https://doi.org/10.1007/978-1-4939-9216-4 © Springer Science+Business Media, LLC, part of Springer Nature 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Humana Press imprint is published by the registered company Springer Science+Business Media, LLC, part of Springer Nature. The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface DNA has become a unique protagonist in the realm of bioorganic chemistry because of its predicable and defined structure, succinct programmability, and known interactions and chemistries. This has led to non-natural DNA mimics, either in part or in whole, becoming integral parts of nanoscaffolds, detection devices, and critical probes in a host of biological applications. This volume aims to highlight the diverse and exciting umbrella of non-natural nucleic acids. As nature has served to inspire, it is hoped that this volume will serve as a means to guide researchers toward a viable method when exploring their own inquiries and to serve as a springboard for new endeavors. Savannah, GA, USA
Nathaniel Shank
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