Photo-electrochemical detection of dopamine in human urine and calf serum based on MIL-101 (Cr)/carbon black
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ORIGINAL PAPER
Photo-electrochemical detection of dopamine in human urine and calf serum based on MIL-101 (Cr)/carbon black Zhi Li 1 & Hongmin Zhang 2 & Qingbing Zha 3 & Chunyang Zhai 1,2 & Wanbin Li 1 & Lixi Zeng 1 & Mingshan Zhu 1 Received: 3 April 2020 / Accepted: 19 August 2020 # Springer-Verlag GmbH Austria, part of Springer Nature 2020
Abstract A new photo-electrochemical sensor based on MIL-101(Cr) MOF/carbon black (CB) is fabricated and characterized. By using differential pulse voltammetry, dopamine (DA) can be effectively detected using a photo-electrochemical MIL-101(Cr)/CB sensor under visible light. The CB acts as the electron bridge to combine with the large specific surface area and photocatalytic feature of MOF, which contribute to the improvements of sensitivity of DA detection. The concentration of the catalyst, pH value, accumulation potential, and accumulation time were also optimized. Furthermore, the electrochemical performances of MIL-101(Cr)/CB sensor was investigated by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), scan rate, electrochemically active surface area (ECSA), and amperometric responses. A detection limit of 0.38 nM (LOD = 3 sb/S, sb = 0.028) and a working range of 1 nM to 2.22 μM has been achieved. The MIL-101(Cr)/CB sensor exhibits excellent reproducibility, stability, and selectivity and also has satisfactory recovery rate for the analysis of real samples including calf serum and human urine. Keywords Photo-electrochemical detection . Metal-organic frameworks . Carbon black . Dopamine
Introduction Dopamine (DA) is well known as an important catecholamine neurotransmitter that can be used to help cells transport chemicals and participate in physiological processes of human body [1]. Therefore, accurate measurement of DA is of great significance for human health. A number of methods are used to detect DA including high-performance liquid Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00604-020-04524-z) contains supplementary material, which is available to authorized users. * Chunyang Zhai [email protected] * Mingshan Zhu [email protected] 1
Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou 511443, People’s Republic of China
2
School of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211, People’s Republic of China
3
Department of Fetal Medicine, First Affiliated Hospital of Jinan University, Guangzhou 510630, People’s Republic of China
chromatography (HPLC), fluorescence, capillary electrophoresis, and so on [2–6]. However, these methods often require timeconsuming sample preparation, a large number of reagents, and operational proficiency. Photo-electrochemical detection is a rapid and new analytical method which has the characteristics of high sensitivity, low cost, simple operation, and miniaturization of instrument [7, 8]. Compared with the traditional electrochemical analysis method, photo-el
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