A Comprehensive Review on Tunnel Field-Effect Transistor (TFET) Based Biosensors: Recent Advances and Future Prospects o

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A Comprehensive Review on Tunnel Field-Effect Transistor (TFET) Based Biosensors: Recent Advances and Future Prospects on Device Structure and Sensitivity N. Nagendra Reddy 1 & Deepak Kumar Panda 1 Received: 25 March 2020 / Accepted: 12 August 2020 # Springer Nature B.V. 2020

Abstract In this fast-growing technological world biosensors become more substantial in human life and the extensive use of biosensors creates enormous research interest among researchers to define different approaches to detect biomolecules. The FET based biosensors have gained a lot of attention among all because of its high detection ability, low power, low cost, label-free detection of biomolecules, and CMOS compatible on-chip integration. The sensitivity of the biosensor inversely proportional to device size since they detect low concentration yields quick response time. Although FET based biosensor is having a lot of advantages among others but the short channel effects (SCE’s) and the theoretical limitation on the subthreshold swing (SS > 60mv/dec) of the FET leads to restrict device sensitivity and also have higher power dissipation due to the thermionic emission of electrons. To avoid these problems researchers focus shifts to the new technology FET based biosensors i.e. TFET based biosensors which are having low power and superior characteristics due to Band to band tunneling of carrier and steep subthreshold swing. This manuscript describes the full-fledged detail about the TFET based biosensors right from unfolding the device evaluation to biosensor application which includes qualitative and quantitative parameters analysis study like sensitivity parameters and different factors affecting the sensitivity by comparing different structures and the mechanisms involved. The manuscript also describes a brief review of different sensitivity parameters and improvement techniques. This manuscript will give researchers a brief idea for developing for the future generation TFET biosensors with better performance and ease of fabrication. Keywords Biosensor . Nanowire . Sensitivity . TFET . Tunneling

1 Introduction The life-threatening bells of humans are at high alert because of the bio-attack that observed form the last few decades’ right forms the HIV to present Coronavirus. They are invisible and spreading with lightning speed without the knowledge of humans and made their life so miserable. Apart from this, the technology improvement has given way for the replacement of classical warheads with bio warheads giving scope for the bio wars. These bio warheads/weapons consist of pathogenic virus or bacteria which spread very silently and took the lives of innocent people at the cutting edge. In this fastest growing technological world, the detection of biohazards * Deepak Kumar Panda [email protected]; [email protected] 1

Microelectronics and VLSI Design Group, School of Electronics, VIT-AP University, Amaravati, Andhra Pradesh 522237, India

(toxic gas of substance) becomes a challenge to every nation and the biose