A new Zn(II)-cluster coordination polymer: selective detection of Al(III) ion and treatment activity on hypotension afte
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ORIGINAL PAPER
A new Zn(II)‑cluster coordination polymer: selective detection of Al(III) ion and treatment activity on hypotension after anesthesia by increasing α receptor expression Huan‑Rong Qiu1 · Shou‑Yuan Tian2 · Zhi‑Jie Yue1 · Zhao‑Jing Xue1 · Hai‑Xia Wang1 · Fang‑Xiao Hong1 Received: 27 April 2020 / Accepted: 14 September 2020 © Iranian Chemical Society 2020
Abstract In this research, a novel coordination polymer (CP) based on Zn(II) ions as nodes [Zn2(1,4-NDC)2(py)2(H2O)] (1, py = pyridine and 1,4-NDCH2 = 1,4-naphthalenedicarboxylic acid) has been produced under hydrothermal reaction condition and then structurally characterized. Furthermore, Zn-complex reveals high sensitivity (with the detection limit of 1.97 × 10−6 M) and fast test time for the Al3+ in the water phase through the fluorescence enhancement method which is rare example in the reported A l3+ detection sensors. The compound was designed for hypotension treatment after anesthesia. First of all, the hypotension animal model was constructed; then, the compound’s protective was evaluated. The real-time reverse transcription-polymerase chain reaction (RT-PCR) was performed, and the α receptor expression on the vascular endothelial cells was determined. In addition to this, the western blot was also conducted for the α receptor expression assessment. Keywords Coordination polymer · Detection sensor · Hypotension · Western blot
Introduction General anesthesia drug is a class of drugs that can inhibit the function of the central nervous system. It temporarily disappears consciousness, sensations and reflexes and relaxes skeletal muscle [1]. It is mainly used for anesthesia before surgery. However, one of the main side effects of the general anesthesia is hypotension. The α receptor on vascular endothelial cells has a significant function in the hypotension; after activated, it could cause contraction of peripheral small blood vessel, which could reverse the hypotension [2, 3]. So, the development of new candidates targeting the α receptor on the vascular endothelial cells was a new strategy for the hypotension treatment. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s13738-020-02068-w) contains supplementary material, which is available to authorized users. * Fang‑Xiao Hong [email protected] 1
Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China
Department of Anesthesiology, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
2
Metal organic frameworks (MOFs) or coordination polymers (CPs) have been extensively used in the fields of heterogeneous catalysis, separation, gas adsorption, fluorescence sensing and biomedicine because of their different interesting structures [4–9]. In order to improve the gas absorption selectivity, fluorescence performance and catalytic performance of CPs, the introduction of secondary structure units based on cluster into the CPs has been extensively studied [10–12]. In comparison wi
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