A review of the botany, traditional uses, phytochemistry and pharmacology of Nepeta tenuifolia Briq.
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A review of the botany, traditional uses, phytochemistry and pharmacology of Nepeta tenuifolia Briq. Mingqiu Shan . Yulan Jiang . Yuanyuan Fu . Yongyi Zhou . Zhihui Lu . Sheng Yu . Hui Yan . Chanchan Liu . Peidong Chen . Beihua Bao . Li Zhang . Qinan Wu
Received: 14 January 2020 / Accepted: 19 October 2020 © Springer Nature B.V. 2020
Abstract Nepeta tenuifolia (N. tenuifolia) is a common aromatic herb that is widespread in East Asia. The aerial parts and spikes can be used as the traditional phytomedicines for the treatment of cold, fever, respiratory diseases, and skin diseases in the clinic and as a vegetable in salads or cooked foods. These applications have lasted for thousands of years due to their outstanding performance. In this review, with the help of PubMed, Web of Science, Google Scholar, Baidu Scholar, and CNKI, we have summarized the research achievements made in recent years on the various aspects of N. tenuifolia, covering botany, traditional uses, processing, phytochemistry, pharmacology, and pharmaceutics. A total of 102 phytochemicals have been found and identified in N. tenuifolia, which were grouped into terpenoids, flavonoids, organic acids and other components, including many bioactive compounds such as pulegone, hesperidin, and rosmarinic acid. This plant has also exhibited antiviral, immunoregulatory, anti-inflammatory, antioxidant and miscellaneous M. Shan (&) · Y. Jiang · Y. Fu · Y. Zhou · Z. Lu · S. Yu · H. Yan · C. Liu · P. Chen · B. Bao · L. Zhang · Q. Wu (&) Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, China e-mail: [email protected] Q. Wu e-mail: [email protected]
bioactivities, including antitumour, antidiabetic, antibacterial, and antithrombus activities. The progress to date has provided basic and strong evidence to support the traditional uses of this herbal medicine. However, the present explanations seem insufficient and unsatisfactory, in term of the relationships between the traditional uses and the modern pharmacological actions, the action mechanisms and the material basis. Therefore, in the future, some comprehensive studies should be well designed for further understanding the development and utilization of N. tenuifolia. Keywords Nepeta tenuifolia · Phytochemistry · Traditional uses · Pharmacology · Herbal medicine Abbreviations AGE Advanced glycation end product BMDM Bone marrow-derived macrophages CHRM1 Cholinergic receptor muscarinic 1 CHRNA7 Cholinergic receptor, nicotinic, alpha 7 COX Cyclooxygenase DNCB 2,4-Dinitrochlorobenzene DPPH 1,1-Diphenyl-2-picrylhydrazyl EV71 Enterovirus 71 GSH-Px Glutathione peroxidase GSH-Rd Glutathione reductase GT Glandular trichome HO-1 Heme oxygenase 1 IFN Interferon IgE Immunoglobulin E
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IL iNOS LPS MAPK MBC MDA MDCK MIC MG MPO NF-κB NLRP3 NQO1 NFATc1 Nrf2 PTGS PGE2 P2X7R SD SOD SRB TCM TD TLR TNF-α
Interleukin Inducible nitric oxide synthase
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