A Review on Nano-Based Drug Delivery System for Cancer Chemoimmunotherapy
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REVIEW
Cite as Nano-Micro Lett. (2020) 12:142 Received: 26 April 2020 Accepted: 11 June 2020 © The Author(s) 2020
https://doi.org/10.1007/s40820-020-00482-6
A Review on Nano‑Based Drug Delivery System for Cancer Chemoimmunotherapy Weiwei Mu1, Qihui Chu1, Yongjun Liu1, Na Zhang1 * * Na Zhang, [email protected] Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 Wenhuaxi Road, Jinan 250012, People’s Republic of China
1
HIGHLIGHTS • The current approaches of cancer immunotherapy were summarized. • The prospects in combination of chemotherapy and immunotherapy were discussed. • The recent progress of nano-based drug delivery systems applied for cancer chemoimmunotherapy was further categorized and reviewed. . ABSTRACT Although notable progress has been made on novel
cancer treatments, the overall survival rate and therapeutic effects are still unsatisfactory for cancer patients. Chemoimmunotherapy, com-
of the drug and enhancing therapeutic effect. Moreover, nano-based
Bio
drug delivery system (NDDS) was applied to encapsulate chemothera-
Na
Several nanocarriers have been approved in clinical cancer chemotherapy and showed significant improvement in therapeutic efficiency ®
compared with traditional formulations, such as liposomes ( Doxil ,
Lipusu®), nanoparticles ( Abraxane®) and micelles (Genexol-PM®).
Metallic/ inorganic NPs
er nd
rim
ls
ge
delivery, tumor microenvironment response and site-specific release.
no
peutic agents and exhibited outstanding properties such as targeted
NDDS
De
cooperating two kinds of treatment mechanism, reducing the dosage
Liposomes er lym es Po cell mi
as a promising approach for cancer treatment, with the advantages of
mi m NP etic s
bining chemotherapeutics and immunotherapeutic drugs, has emerged
Au NPs Cu NPs
Fe NPs
The applications of NDDS to chemoimmunotherapy would be a powerful strategy for future cancer treatment, which could greatly enhance the therapeutic efficacy, reduce the side effects and optimize the clinical outcomes of cancer patients. Herein, the current approaches of cancer immunotherapy and chemoimmunotherapy were discussed, and recent advances of NDDS applied for chemoimmunotherapy were further reviewed. KEYWORDS Cancer therapy; Chemotherapy; Immunotherapy; Chemoimmunotherapy; Nano-based drug delivery system
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1 Introduction Cancer is still the main cause of death for patients worldwide with increasing incidence [1, 2], and the research into cancer treatment is under the spotlight. Surgery, radiotherapy, chemotherapy and immunotherapy, as well as those combinational regimens are now the main clinical strategies [3]. Among those, immunotherapy is now considered as the potentially powerful approach to overcome the cancer due to the completely different way for cancer treatment, which acts by modulating the systemic immune system rather than focusing on the tumor
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