Adipocytokines, Energy Balance, and Cancer
Adipocytokines provide the circuitry by which adipose tissue communicates among its component cells which include adipocytes, stromal cells, immune cells and vascular elements, with adipose tissue depots in other locations throughout the body and with oth
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Ofer Reizes Nathan A. Berger Editors
Adipocytokines, Energy Balance, and Cancer
Energy Balance and Cancer Volume 12
Series Editor: Nathan A. Berger, Case Western Reserve University, School of Medicine, Cleveland, OH, USA
More information about this series at http://www.springer.com/series/8282
Ofer Reizes • Nathan A. Berger Editors
Adipocytokines, Energy Balance, and Cancer
Editors Ofer Reizes Department of Cellular and Molecular Medicine Cleveland Clinic Lerner Research Institute Cleveland, OH, USA
Nathan A. Berger Center for Science, Health and Society Case Western Reserve University Cleveland, OH, USA
ISSN 2199-2622 ISSN 2199-2630 (electronic) Energy Balance and Cancer ISBN 978-3-319-41675-5 ISBN 978-3-319-41677-9 (eBook) DOI 10.1007/978-3-319-41677-9 Library of Congress Control Number: 2016948729 © Springer International Publishing Switzerland 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Preface
Adipose tissue, composed of adipocytes, stromal cells, immune and inflammatory cells, and vascular components, was initially considered a depot, storing fuel in the form of fats during times of energy excess and providing fuel for body functions in time of energy needs. Regulation of storage, release, and utilization has been found to be due to the interaction of a complex array of signaling factors that may act locally and/or systemically by autocrine, paracrine, and endocrine mechanisms. These include a variety of growth factors, hormones, and other regulatory agents synthesized in brain, endocrine organs, muscle, gastrointestinal, and adipose tissue itself. When synthesized and secreted in adipose tissues, these factors are designated adipocytokines; they have major physiologic and behavioral effects and their concentrations fluctuate in resp
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