Aspirin
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Urticaria, angioedema and anaphylaxis: case report A man with suspected aspirin-sensitive respiratory disease (ASRD) developed urticaria, angioedema and anaphylaxis after receiving aspirin. At 58 years of age, the man presented with late onset difficult asthma. He also had a history of chronic rhinitis and recurrent nasal polyposis. He was diagnosed with suspected ASRD and advised to avoid NSAIDs. He also commenced a low salicylate diet. Eighteen months later, he was admitted with exacerbation of his asthma. He subsequently developed dyspnoea, chest tightness and tachycardia. He was diagnosed with a possible acute coronary syndrome and transferred to a coronary care unit. His suspected ASRD diagnosis was overlooked and he received aspirin 300mg [route not stated]. He quickly developed widespread urticaria, then angioedema, wheeziness, throat closure and hypotension. The man received steroids, antihistamines, bronchodilators, oxygen and epinephrine [adrenaline] with good response. He was diagnosed with an adverse reaction to aspirin. His asthma then settled and cardiology tests were normal. He was discharged after a brief hospitalisation and received outpatient follow-up for his asthma. Abayaratne D, et al. Recognising the risk of aspirin-sensitive respiratory disease in a patient with asthma who has previously tolerated aspirin. Primary Care Respiratory Journal 20: 214-217, No. 2, Jun 2011. Available from: URL: http:// 803057524 dx.doi.org/10.4104/pcrj.2011.00001 - United Kingdom
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Reactions 23 Jul 2011 No. 1361
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