Features of In Vitro Degradation and Physical Properties of a Biopolymer and In Vivo Tissue Reactions in Comparison with
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Bulletin of Experimental Biology and Medicine, Vol. 170, No. 1, November, 2020 BIOTECHNOLOGIES
Features of In Vitro Degradation and Physical Properties of a Biopolymer and In Vivo Tissue Reactions in Comparison with Polypropylene I. A. Eisenakh1, O. I. Bondarev2, V. G. Mozes3, G. A. Lapii1, and E. L. Lushnikova1
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 170, No. 7, pp. 106-111, July, 2020 Original article submitted May 7, 2020 We compared in vitro degradation and physical properties of polypropylene and a biodegradable polymer synthesized by electrospinning and consisting of 65% polycaprolactone and 35% polytrimethylene carbonate as a possible alternative material for use in surgery for pelvic floor muscle failure. Samples of the studied polymers were implanted to 10 male Wistar rats into the interfascial space on the back (polypropylene on the right side and biodegradable polymer on the left side). The synthesized biopolymer was characterized by elongation and tear resistance, similar to those of polypropylene. During the period from the third to the sixth month after implantation, the area of fibrosis around individual polypropylene and biopolymer fibers increased by 16.7 and 107.9%, respectively, while remaining reduced compared to polypropylene. The total fibrosis area in 6 months after implantation of polypropylene and biopolymer samples significantly increased by 18% (p=0.0097) and 48% (p=0.05), respectively, i.e. fibrosing processes were more intense in case of biopolymer. Induction of more pronounced fibrosis can be an advantage of the synthesized biopolymer when choosing the material for fabrication of implants and their use for correction of incompetence of the ligamentous and muscular apparatus. Key Words: synthetic implants; physical properties; degradation; tissue reactions Biodegradation is one of the main features of polymers, which determine their possible use in surgery. Therefore, the study of biodegradation of polymers in tissues is a prerequisite for the development of algorithms for their possible use for medical purposes. Polypropylene widely used in surgery for pelvic muscle failure causes a local inflammatory reaction, primarily in the proliferative phase, with the formation of the connective tissue that acts as a frame reinforced 1 Institute of Molecular Pathology and Pathomorphology, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia; 2Novokuznetsk State Institute for Further Training of Physicians — Affiliated Branch of Russian Medical Academy of Continuous Professional Education, Ministry of Health of the Russian Federation, Novokuznetsk, Russia; 3Kemerovo State Medical University, Ministry of Health of the Russian Federation, Kemerovo, Russia. Address for correspondence: [email protected]. I. A. Eisenakh
with polypropylene fibers [4,7]. The vaginal wall often reacts to a foreign body with the formation of erosion. Prolapse recurrencies after plastic surgery with polypropylene implants sometimes make the task of reconstru
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