Mitomycin
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Mitomycin Periocular allergic contact dermatitis: case report A 63-year-old woman underwent excision of a left conjunctival squamous cell carcinoma with cauterisation of the base. Mitomycin 0.2 mg/mL was administered to the local area with a sponge for approximately 2 minutes. Topical 0.02% mitomycin eye drops four times per day [dosage not clearly stated] were then prescribed to reduce the risk of recurrence. Forty-eight hours later, she presented with a severe dermatitis involving her left eyelids. Patch testing with mitomycin 0.01% under a Finn chamber on the skin showed, 48 hours later, that she was allergic to the mitomycin preparation (type IV hypersensitivity). The topical mitomycin was discontinued and she received treatment with a topical corticosteroid. Her periocular allergic contact dermatitis subsequently resolved. Cumurcu T, et al. Periocular allergic contact dermatitis following topical Mitomycin C eye drop application. Cutaneous and Ocular Toxicology 30: 239-240, No. 3, Sep 2011. Available from: URL: http:// 803060567 dx.doi.org/10.3109/15569527.2011.552898 - Turkey
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Reactions 24 Sep 2011 No. 1370
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