Mitomycin
- PDF / 141,308 Bytes
- 1 Pages / 623.591 x 841.847 pts Page_size
- 72 Downloads / 169 Views
1
S
Fatal acute myeloid leukaemia?: case report A 44-year-old woman developed acute myeloid leukaemia (AML) following chemotherapy with mitomycin for recurrent pancreatic cancer. She subsequently died of refractory leukaemia. The woman underwent intraperitoneal hyperthermic chemotherapy with mitomycin 40mg heated to 40°C and infused for 2 hours. Nine months later, she developed leucocytosis with circulating blasts, and bone pain. Bone marrow examination showed 66% myeloblasts, positive for HLA-DR, CD11c, CD13, CD15, CD33 and for myeloperoxidase staining, consistent with AML-M4 with eosinophilia. Cytogenic bone marrow analysis showed 46,XX,inv(16)(p13q22)(20). The woman received cytarabine and idarubicin, with complete remission of her AML, then consolidation therapy with cytarabine. About 7 months after her initial AML diagnosis, her AML recurred. She achieved a second remission following treatment with cytarabine, etoposide and daunorubicin. However, she relapsed again shortly after, and died of refractory leukaemia about 1 year and 10 months after her mitomycin treatment. Author comment: "Whether intraperitoneal [mitomycin] with or without hyperthermia has any role in the onset of AML in our patient is uncertain." Mitchell J, et al. Acute myeloid leukemia following intraperitoneal hyperthermic mitomycin C. Leukemia and Lymphoma 47: 947-949, No. 5, May 2006 801043803 USA
0114-9954/10/1117-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 2 Sep 2006 No. 1117
Data Loading...
