Neurotrophic Factors Methods and Protocols
This volume collects protocols and procedures utilizing cellular, tissue, and whole animal models that can be applied to the investigation of neurotrophic factors and other agents impacting on these systems. It begins with chapters on the culture of neuro
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Stephen D. Skaper Editor
Neurotrophic Factors Methods and Protocols Second Edition
Methods
in
Molecular Biology
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Neurotrophic Factors Methods and Protocols Second Edition
Edited by
Stephen D. Skaper Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy
Editor Stephen D. Skaper Department of Pharmaceutical and Pharmacological Sciences University of Padova Padova, Italy
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-7570-9 ISBN 978-1-4939-7571-6 (eBook) https://doi.org/10.1007/978-1-4939-7571-6 Library of Congress Control Number: 2017959194 © Springer Science+Business Media, LLC 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media, LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface The Nobel laureate and neurobiologist Eric Kandel once described neuroscience as the “last frontier” of science. Nervous system development evolves from the well-orchestrated processes of neural induction, cell proliferation, differentiation, cell migration, survival, and synapse formation. This complex machinery responds to a multitude of environmental cues, among these being neurotrophic factors: secreted proteins that promote neurite outgrowth, neuronal cell differentiation, and survival both in vivo and in vitro. Nerve growth factor (NGF) is the founding and best characterized member of the neurotrophin family of neurotrophic polypeptides and was discovered almost six decades ago by the pioneering Italian neurobi
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