Quetiapine increases risk of suicide and stroke
- PDF / 170,636 Bytes
- 1 Pages / 595.245 x 841.846 pts (A4) Page_size
- 73 Downloads / 179 Views
1
Quetiapine increases risk of suicide and stroke Treatment with quetiapine in combination with other antidepressants appears to increase the risk of selfinjurious behaviour and suicide in younger adults, and stroke in older adults, according to findings of an AstraZeneca-funded study published in Drug Safety. This post-authorisation safety study which was a commitment to the European Medicines Agency (EMA) used data from Swedish registers (National Patient Register, Total Population Register, and Cause of Death Register) to evaluate the risks of adverse events in adults who filled a prescription for quetiapine monotherapy, quetiapine combination therapy or antidepressant monotherapy compared with antidepressant combination therapy between 2011 and 2014, or received no treatment. In total, 7421 quetiapine users and 281 303 antidepressant users were included, and nested case-control studies were conducted with each case matched to five controls. Overall, quetiapine combination therapy was associated with an increased risk of all-cause mortality compared with antidepressant combination therapy (adjusted odds ratio [aOR] 1.31; 95% CI 1.12, 1.54). However, stratification by age showed that the risk of mortality was only increased in elderly patients (≥65 years), and post-hoc analysis found there was no increase in mortality when patients with Parkinson’s disease were excluded. The risk for self-harm and suicide was also increased with quetiapine combination therapy (aOR 1.53; 95% CI 1.31, 1.79), but stratification by age showed that this risk was only increased in patients aged 18–64 years. Quetiapine combination therapy was associated with an increased risk of stroke in elderly patients (aOR 1.47; 95% CI 1.01, 2.12), and an increased risk of basal ganglia disorders (extrapyramidal disorders; aOR 6.15; 95% CI 3.57, 10.58) and somnolence (aOR 2.41; 95% CI 1.42, 4.11). Neither quetiapine monotherapy nor quetiapine combination therapy were associated with an increased risk of acute myocardial infarction or diabetes mellitus. "Risks for all-cause mortality, self-harm and suicide, and stroke in older patients may be higher among patients treated with quetiapine and antidepressant combination therapy," concluded the authors. Reutfors J, et al. A Post-Authorization Safety Study of Quetiapine as Antidepressant Treatment in Sweden: Nested Case-Control Analyses of Select Outcomes. Drug Safety : 17 Dec 2019. Available from: URL: https:// 803442575 doi.org/10.1007/s40264-019-00889-0
0114-9954/20/1785-0001/$14.95 Adis © 2020 Springer Nature Switzerland AG. All rights reserved
Reactions 4 Jan 2020 No. 1785
Data Loading...
