Quetiapine
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Hypoglycaemia: case report A 50-year-old woman developed hypoglycaemia during treatment with quetiapine for schizophrenia. The woman was hospitalised for aggravation of her schizophrenia, presenting with auditory hallucinations and persecutory delusions. She was receiving low-dose risperidone prior to admission and due to a previous experience of risperidone-induced parkinsonism at higher doses she was switched to olanzapine. Despite first increasing the dosage of olanzapine and then switching to aripiprazole her symptoms did not improve. Quetiapine 100 mg/day [route not stated] was initiated on day 71 then increased to 300 mg/day on day 76 and again to 400 mg/day on day 83 leading to stabilisation of her psychotic symptoms. She then experienced sleepiness and general fatigue [time to reaction onset not stated]. An oral glucose tolerance test was conducted which showed a glucose level of 56 mg/dL. Quetiapine-induced hypoglycaemia was suspected. Quetiapine was discontinued and the woman switched to blonanserin. Her sleepiness and general fatigue resolved following the switch. A repeat oral glucose tolerance test was conducted on day 132 following which no hypoglycaemia was detected. Her auditory hallucinations and persecutory delusions improved and she was discharged on day 180. Author comment: "We herein report a case in which hypoglycemia induced by quetiapine was improved after a switch to blonanserin." Suzuki Y, et al. Improvement in quetiapine-induced hypoglycemia following a switch to blonanserin. Psychiatry and Clinical Neurosciences 66: 370-371, No. 4, Jun 2012. Available from: URL: http://dx.doi.org/10.1111/ 803074954 j.1440-1819.2012.02338.x - Japan
0114-9954/10/1414-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 11 Aug 2012 No. 1414
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