Regenerative Therapy Using Blood-Derived Stem Cells
Regenerative medicine is the emerging science of how we can support our body to repair itself and encompasses innovative strategies to facilitate recovery after organ injury. Several types of blood-derived stem cells can be easily procured and have the po
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Series Editor Kursad Turksen, Ph.D. [email protected]
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David S. Allan
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Dirk Strunk
Editors
Regenerative Therapy Using Blood-Derived Stem Cells
Editors David S. Allan Ottawa Hospital Research Institute University of Ottawa ON, Canada [email protected]
Dirk Strunk Center for Medical Research (ZMF) Medical University of Graz Graz, Austria [email protected]
ISBN 978-1-61779-470-4 e-ISBN 978-1-61779-471-1 DOI 10.1007/978-1-61779-471-1 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2011939470 © Springer Science+Business Media, LLC 2012 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)
Preface
Blood has long been viewed as a conduit for therapy, stemming from the ancient days of phlebotomy to remove evil humors to the development of successful blood transfusions to replace missing blood components. The identification and characterization of hematopoietic stem cells by Drs. Till and McCulloch revolutionized the field and soon after, non-hematopoietic stem and progenitor cells were characterized from the blood and bone marrow. Some of these cell types and various blood-derived cell lineages are involved in the repair of various types of tissue damage that span the spectrum of medical disorders. The goal of this book is to provide an up-to-date review of the various types of blood-derived cells with regenerative capacity, identify opportunities for intervention by examining specific clinical applications, and recognize the regulatory environment that will encompass future therapies in regenerative medicine. Through the contributors to this volume, we have succeeded in providing insight on numerous blood-derived cell types, including endothelial progenitors, mesenchymal stromal/stem cells, umbilical cord blood-derived undifferentiated somatic stem cells and others. Further, the concept of using umbilical cord blood is discussed throughout the book and several authors describe the current status of regenerative therapy for cardiac disease and neurological disorders. Technical and conceptual issues such as ex vivo expansion and the generation of induced pluripotent stem cells are covered and regulatory insight from variou
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