Systems Biology of Metabolic and Signaling Networks Energy, Mass and
Systems Biology represents a new paradigm aiming at a whole-organism-level understanding of biological phenomena, emphasizing interconnections and functional interrelationships rather than component parts. The study of network properties, and how they con
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Miguel A. Aon Valdur Saks Uwe Schlattner Editors
Systems Biology of Metabolic and Signaling Networks Energy, Mass and Information Transfer
Springer Series in Biophysics 16 Series editor: Boris Martinac
For further volumes: http://www.springer.com/series/835
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Miguel A. Aon • Valdur Saks • Uwe Schlattner Editors
Systems Biology of Metabolic and Signaling Networks Energy, Mass and Information Transfer
Editors Miguel A. Aon Johns Hopkins University School of Medicine Baltimore, MD USA
Valdur Saks Uwe Schlattner Laboratory of Fundamental and Applied Bioenergetics University Joseph Fourier Grenoble France
Series editor: Boris Martinac Molecular Cardiology and Biophysics Division Victor Chang Cardiac Research Institute Darlinghurst (Sydney), Australia
ISSN 0932-2353 ISSN 1868-2561 (electronic) ISBN 978-3-642-38504-9 ISBN 978-3-642-38505-6 (eBook) DOI 10.1007/978-3-642-38505-6 Springer Heidelberg New York Dordrecht London Library of Congress Control Number: 2013949537 © Springer-Verlag Berlin Heidelberg 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
During the last decade, life sciences have experienced a major shift from analytical to integrative approaches that can be globally defined as Systems Biology. In this overal
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