Topical gel with ethyl cellulose based microsponges loaded with clindamycin hydrochloride for acne treatment
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ORIGINAL RESEARCH
Topical gel with ethyl cellulose based microsponges loaded with clindamycin hydrochloride for acne treatment Ivana Dimitrovska . Tanja Olumceva . Elena Markova . Monika Kostoska . Lea Taneska . Marija Petrushevska . Vasil Makrievski . Jovica Todorov . Dushko Shalabalija . Ljubica Mihailova . Riste Popeski Dimovski . Marija Glavas Dodov . Maja Simonoska Crcarevska
Received: 8 January 2020 / Accepted: 5 June 2020 Ó Springer Nature B.V. 2020
Abstract This study describes development of a dosage form for acne treatment. A topical semi-solid dosage form—gel with clindamycin-hydrochloride (CM-HCl) loaded ethyl cellulose based microsponges (MSP). Central composite experimental design was used for optimization of the formulation in means of particle size and drug loading. CM-HCl MSP optimal formulation was prepared and characterized in aspect of: particle size (D50-14.9 lm) and particle size distribution (Span-1.979); shape (spherical) and morphology (porous); FTIR spectra; drug content (CMHCl/polymer (mg/mg)-1.2544) and drug release with mean dissolution time (MDT) of 4.51 h. Chitosan
(2%) was used as a gelling agent for the optimal sample formulation. The gel showed pseudoplastic behavior and high value of spreading capacity (263.64% spreading after 5 min). It was translucent without presence of foreign particles and had typical light-yellow colour, pH value of 5.36 ± 0.15 and MDT of 7.17 h. Stability studies performed at 25° ± 2 °C/60% ± 5% RH and 40° ± 2 °C/75% ± 5% RH for a period of 6 months were in favor of the stability of the designed topical semi-solid dosage form. Keywords Clindamycin hydrochloride Microsponges Acne Topical semi-solid dosage form Central composite experimental design
Ivana Dimitrovska and Tanja Olumceva have contributed equally to this work. I. Dimitrovska T. Olumceva E. Markova M. Kostoska L. Taneska D. Shalabalija L. Mihailova M. Glavas Dodov M. Simonoska Crcarevska (&) Faculty of Pharmacy, Institute of Pharmaceutical Technology, Center of Pharmaceutical Nanotechnology, University of ‘‘Ss. Cyril and Methodius’’, Majka Tereza 47, 1000 Skopje, Republic of North Macedonia e-mail: [email protected]; [email protected] M. Petrushevska Department of Preclinical and Clinical Pharmacology and Toxicology, Medical Faculty, University of ‘‘Ss. Cyril and Methodius’’, 50 Divizija 6, 1000 Skopje, Republic of North Macedonia
V. Makrievski J. Todorov Faculty of Natural Sciences and Mathematics, Institute of Chemistry, University of ‘‘Ss. Cyril and Methodius’’, Arhimedova 5, 1000 Skopje, Republic of North Macedonia R. Popeski Dimovski Faculty of Natural Sciences and Mathematics, Institute of Physics, University of ‘‘Ss. Cyril and Methodius’’, Arhimedova 3, 1000 Skopje, Republic of North Macedonia
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Cellulose
Introduction Acne is one of the most common skin conditions that affect people across the globe (Bickers et al. 2006). Acne commonly starts during puberty between the ages of 10 and 13 and t
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