Potential of antimicrobial topical gel with synthesized biogenic silver nanoparticle using Rhodomyrtus tomentosa leaf ex
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ORIGINAL RESEARCH PAPER
Potential of antimicrobial topical gel with synthesized biogenic silver nanoparticle using Rhodomyrtus tomentosa leaf extract and silk sericin Julalak C. Ontong . Sudarshan Singh . Ozioma F. Nwabor . Sarunyou Chusri . Supayang P. Voravuthikunchai
Received: 30 January 2020 / Accepted: 13 July 2020 Ó Springer Nature B.V. 2020
Abstract Objective Silver nanoparticles synthesized using Rhodomyrtus tomentosa leaf extract and silk sericin were used to functionalize carbopol 940 gel for topical applications. Results UV–vis spectra presented surface plasmon resonance at 426 nm, transmission electron microscopy revealed that nanoparticles were spherical with an average size of 25–50 nm. X-ray diffraction presented crystalline silver nanoparticles with zeta potential of & - 30 mV. FTIR spectra showed a reduction of silver nitrate indicated by the shift in –OH
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10529-020-02971-5) contains supplementary material, which is available to authorized users. J. C. Ontong Cosmetic Technology and Dietary Supplement Products Program, Faculty of Agro and Bio Industry, Thaksin University, Ban Pa Phayom, Phatthalung 93210, Thailand J. C. Ontong S. Chusri Division of Infectious Diseases, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand S. Singh O. F. Nwabor S. P. Voravuthikunchai (&) Excellence Research Laboratory on Natural Products, Department of Microbiology, Faculty of Science and Natural Product Research Center of Excellence, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand e-mail: [email protected]
at 2958 cm–1. The silver nanoparticle demonstrated broad-spectrum antimicrobial activity against Grampositive, Gram-negative and fungi with MIC ranging between 0.26 and 2.10 lg mL-1, respectively. MIC of hydrogel ranged between 1.05–2.10 lg mL-1 with cell viability of 89%. Spreadability and extrudability of gel were 9.3 ± 0.85 s and 19.85 ± 0.03%, respectively with first order of fickian diffusion. Conclusions The silver nanoparticle gel exhibited an effective antimicrobial property, hence can be exploited for topical applications. Keywords Rhodomyrtus tomentosa Silk sericin Silver nanoparticles Antimicrobial Cytotoxicity Hydrogel
Introduction Nano-structured materials have gained wide popularity due to excellent properties and low cost of synthesis. Silver nanoparticles (AgNPs) have demonstrated notable bioactive qualities, with wide usage as antimicrobial agents. However, conventional chemical and physical methods employed in the synthesis of nanoparticles are energy-consuming and hazardous to the environment. Thus, the use of eco-friendly biomaterials such as agricultural waste products and plant phytochemicals are important strategies in the
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development of the green synthesis approach. The use of antimicrobial green synthesized AgNPs as functio
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